左乙拉西坦单药治疗婴幼儿癫痫56例临床观察  

Levetiracetam monotherapy in the treatment of infantile epilepsy in 56 cases

作　　者：程艳[1] 谭忠友[1] 何扬帆[1] 谭汉梅[1] 莫运波[1] 甘萍[1] 

机构地区：[1]重庆三峡中心医院儿童分院儿内一科,万州404000

出　　处：《重庆医科大学学报》2012年第11期1022-1024,共3页Journal of Chongqing Medical University

摘　　要：目的：研究左乙拉西坦（Levetiracetam,Lev）单药治疗不同类型婴幼癫痫的临床疗效和安全性。方法：采用自身对照随访研究56例不同类型婴幼癫痫患儿使用Lev单药口服治疗,Lev起始剂量10 mg/（kg.d）,分2次服用,每3-7 d增加5-10mg/（kg.d）,维持剂量20-40 mg/（kg.d）;经1-2周增加至平均剂量为35 mg/（kg.d）。治疗后观察疗效和不良反应。结果：完全控制发作29例,占51.78%;有效15例,占26.78%;无效12例,占21.44%。不良反应以厌食、嗜睡、情绪激动,行为异常为主。结论：Lev单药治疗婴幼儿各型癫痫均有效,尤其对于部分性发作、肌阵挛发作等具有较好治疗效果,且不良反应轻,是一种安全性好、疗效佳的抗癫痫新药,对婴幼儿癫痫的治疗值得推广使用。Objective：To study the efficacy and safety of Levetiracetam（Lev）monotherapy for different types of infantile epilepsy.Methods：Self controlled follow-up study was conducted for 56 patients with different types of infantile epilepsy using Lev oral monotherapy.Dose of Lev was initially 10 mg/（kg.d）（being administered two times a day）,increased by 5-10 mg/（kg.d）every 3-7 d,maintained at 20-40 mg/（kg.d）and finally was increased to 35 mg/kg within 1-2 week.Efficacy and adverse reaction were observed after the treatment.Results：Complete seizure control was found in 29 cases,accounting for 51.78%;effective in 15 cases,accounting for 26.78%;invalid in 12 cases,accounting for 21.44%.Adverse reactions were mainly anorexia,lethargy,emotional rage and behavioral abnormality.Conclusions：Lev monotherapy is effective and safe in the treatment of different types of infantile epilepsy,especially for complex partial seizures and myoclonic seizures.With few adverse reactions,it is a good antiepileptic drug for epilepsy in infants and worth popularizing.

关 键 词：癫痫 左乙拉西坦 婴幼儿 

分 类 号：R748[医药卫生—神经病学与精神病学]