抑郁症患者前额脑电功率改变以及与抗抑郁剂疗效的相关性  

Study of relevance of prefrontal brain electrical power change and antidepressant treatment effect in patients with major depression

作　　者：钱卫娟[1] 刘刚[1] 任方芳[1] 

机构地区：[1]南京医科大学附属脑科医院精神科,210029

出　　处：《临床精神医学杂志》2012年第5期319-321,共3页Journal of Clinical Psychiatry

摘　　要：目的:探讨抑郁症患者前额脑电功率与抗抑郁剂疗效的关系。方法:对40例抑郁症患者(研究组)入院1周内行脑电地形图检查,并和32例正常对照组进行对照分析;同时对患者在治疗前后进行HAMD评定。结果:前额脑波α1,δ,θ频段功率研究组较对照组明显升高,组间差异具有统计学意义(P<0.05);研究组左前额δ波功率与HAMD第2周减分率有统计学意义的负相关(P<0.05);研究组左前额β波功率与HAMD第6周减分率有统计学意义的负相关(P<0.05)。结论:抑郁症患者可能存在前额功能损伤;其抗抑郁剂治疗起效时间可能与左前额δ波功率有关,且左前额β功率越高可能提示疗效欠佳。Objective：To explore the relationship of prefrontal brain electrical power change and antidepressant treatment effect in patients with major depression.Method：40 patients with major depression （study group） and 32 age-and education-matched health control （control group） were investigated.All patients were examined by brain electricity area mapping （BEAM） within a week after admission.Hamilton depressive symptoms scales （HAMD） was applied to evaluate efficacy.Results：The power of prefrontal α1,δ,θ wave in study group was significantly higher than that of control group （P0.05）.There was a negative correlation between left prefrontal δ wave power and reduction rate of HAMD after 2 weeks treatment in study group（P0.05）.There was a negative correlation between left prefrontal β wave power of study group and reduction rate of HAMD after 6 weeks treatment（P0.05）.Conclusion：Patients with major depression may have prefrontal electrophysiological dysfunction.Left prefrontal δ wave power may be the leading influence factor for onset of antidepressant treatment effects,and high left prefrontal β wave power may implies poor treatment effect in patients with major depression.

关 键 词：抑郁症 前额脑电功率 抗抑郁剂疗效 

分 类 号：R749.4[医药卫生—神经病学与精神病学]