亚甲基四氢叶酸还原酶与肺癌的关联性研究  

Association between genetic polymorphisms of MTHFR and risk of lung cancer

作　　者：佟晶[1] 马建忠[1] 

机构地区：[1]中国医科大学基础医学院,辽宁沈阳110001

出　　处：《中国预防医学杂志》2012年第10期751-754,共4页Chinese Preventive Medicine

摘　　要：目的研究中国大陆人群亚甲基四氢叶酸还原酶(MTHFR)基因遗传位点C677T和A1298C多态性与肺癌的关联性。方法通过PubMed和CNKI等数据库检索有关MTHFR基因与肺癌的文献,收集和整理中国大陆人群MTHFR基因遗传位点C677T和A1298C与肺癌有关4 781例数据,进行Meta分析和关联性研究。结果 MTHFR基因遗传位点C677T的等位基因分布和基因型分布对应的假设检验的概率分别为2.6×10-3、9.4×10-3,表明病例对照差异有统计学意义(P<0.05);Meta分析对等位基因T的优势比OR值(95%CI)为1.28(1.16～1.41)。遗传位点A1298C的等位基因分布对应的假设检验概率分别为0.713和0.944,说明假设检验差异无统计学意义(P>0.05),Meta分析对等位基因A的优势比OR值(95%CI)为1.04(0.85～1.27)。结论 MTHFR基因的单核苷酸C677T多态性是中国大陆人群肺癌的遗传变异位点,A1298C多态性不是中国大陆人群肺癌的风险因素。Objective To assess the association between MTHFR polymorphisms and risk of lung cancer in China's Mainland.Methods Data of total 4781 study-related cases and controls were obtained from literatures by exclusively searching in the database of PubMed and CNKI and were analyzed using Meta.Results There were significant differences in the frequency of C677T allele and genotype distribution between cases and controls（P=2.6×10-3,P=9.4×10-3）.Meta-analysis revealed that the pooled OR（95%CI） of C677T T allele was 1.28（1.16-1.41）.However no significant differences were found in the frequency of A1289C allele and genotype distribution between cases and controls（P=0.713,P=0.944） and pooled OR（95%CI） of A1289C A allele was 1.04（0.85-1.27）.Conclusions It is single-nucleotide polymorphism of C677T not A1289C in the MTHFR gene which is closely associated with risk of lung cancer among mainland population in China.

关 键 词：肺癌 亚甲基四氢叶酸还原酶 META分析 基因组关联性研究 

分 类 号：R734.2[医药卫生—肿瘤]