大剂量奥美拉唑治疗老年胃溃疡合并出血患者再出血的疗效分析  

Efficacy analysis of high-dose omeprazole treatment in gastric ulcer hemorrhage in elderly patients with re-bleeding

作　　者：董顺宝 邵玉东[1] 何红见[1] 肖天利[2] 

机构地区：[1]四川省通江县人民医院内一科,636700 [2]第三军医大学附属西南医院消化内科,重庆400038

出　　处：《白求恩军医学院学报》2012年第4期292-293,共2页Journal of Bethune Military Medical College

摘　　要：目的分析大剂量奥美拉唑治疗老年胃溃疡合并出血患者再出血的疗效。方法我院收治的106例老年胃溃疡合并出血止血后再出血患者随机分为两组,观察组53例,采用大剂量奥美拉唑进行治疗,对照组53例,采用小剂量奥美拉唑进行治疗,对两组患者临床治疗效果进行分析对比。结果观察组53例中,30d内再出血5例(其中3d内再出血4例),发生率为9.4%,对照组53例中30d内再出血14例(其中3d内再出血11例),发生率为26.4%,观察组再出血率低于对照组(P<0.05)。两组均未出现并发症,个别患者于治疗中出现轻微头痛、恶心,于4d内自行消失;两组均无复发。结论对老年胃溃疡合并出血再出血患者行大剂量奥美拉唑治疗,无毒副作用,疗效好,复发率低,可作为治疗该病的首选方法。Objective To analyze the efficacy of high-dose omeprazole treatment of elderly gastric ulcer patients with second time hemorrhage.Methods 106 elderly patients with gastric ulcer and bleeding,and second time bleeding patients were randomly divided into experimental group and control group（n=53 in experimental group and n=53 in high-dose omeprazole treatment and control group）and small doses of omeprazole treatment was applied,and the clinical outcomes of two groups were analyzed and compared.Results 53 patients in the experimental group,3d re-bleeding in four cases within 30d,and bleeding rates were 9.4%;11 cases of re-bleeding within 3d,14 cases within 30d and re-bleeding rates were 26.4%.The experimental group＇s re-bleeding rate was significantly lower than that of the control group.The two groups of patients did not have any complications due to omeprazole drug,with a few patients suffering from mild headaches,nausea,and the symptoms were gone within 4d in two groups of patients after the treatment,bleeding was effectively controlled with no recurrence.Conclusion High-dose omeprazole is effective in treating hemorrhage in elderly gastric ulcer re-bleeding patients with no toxic side effects,and can significantly stop the bleeding,protect the gastric mucosa,with a low rate of recurrence and is preferred in clinic.

关 键 词：奥美拉唑 胃溃疡 出血 疗效 

分 类 号：R573.1[医药卫生—消化系统]