防龋疫苗  

Vaccine against dental caries

作　　者：许庆安[1] 

机构地区：[1]武汉大学口腔医学院牙体牙髓科,武汉430079

出　　处：《中国实用口腔科杂志》2012年第10期591-594,共4页Chinese Journal of Practical Stomatology

基　　金：国家自然科学基金(81000435)

摘　　要：龋病是人类最常见的感染性疾病之一,严重威胁人群口腔健康。变形链球菌组细菌,主要是Streptococcus mutans和Streptococcus sobrinus被认为是最重要的致龋微生物。动物实验和临床研究已证实,通过免疫学干预致龋菌在口腔的定植能够影响龋病的发生,防龋疫苗有望成为一种新的龋病预防措施。Dental caries remain one of the most common infectious diseases in mankind and seriously threaten the oral health of populations. Mutans streptococci , mainly Streptococcus mutans and Streptococcus sobrinus, have been recognized as the most important cariogenic microorganisms. Animal experiments and clinical trials have demonstrated that immuno-logical interventions against colonization of mutans streptococ-ci in oral cavity can influence the pathogenesis of dental caries , and anti-caries vaccines may become a new way to fight against dental-caries in the future.

关 键 词：龋病 疫苗 黏膜免疫 

分 类 号：R78[医药卫生—口腔医学]