脑囊虫病临床异质性、病理变化与免疫反应  

Related immune response of clinic heterogeneity and pathology in neurocysticercosis

作　　者：陈小华[1] 谷俊朝[1] 

机构地区：[1]首都医科大学附属北京友谊医院,北京热带医学研究所,北京100050

出　　处：《中国病原生物学杂志》2012年第10期796-799,共4页Journal of Pathogen Biology

基　　金：国家自然科学基金-青年科学基金项目(No.81101269)

摘　　要：脑囊虫病,由猪囊尾蚴寄生于中枢神经系统引起。脑囊虫病临床异质性表现为从无症状到颅内高压、脑积水、蛛网膜炎、癫痫,甚至死亡。脑囊虫病病理变化表现为血脑屏障破坏、脑实质肉芽肿形成、局部及外周多种免疫细胞共同参与。脑囊虫病的临床异质性与病理变化均与宿主抗猪囊尾蚴免疫反应密切相关。本文就与脑囊虫病临床异质性、病理变化相关的抗囊尾蚴免疫、影响因素(囊尾蚴发育阶段、大小、数量、位置、基因组学;宿主年龄、性别、遗传背景)与免疫机制等做一综述。Neurocysticercosis（NC） is caused by infection of the central nervous system with Taenia solium metacestode（Cysticercus）.Clinical heterogeneity of NC can range from a totally asymptomatic course to severe illness,with intracranial hypertension,hydrocephalus,arachnoiditis,seizures,and even death.Pathologic changes caused by NC include breakdown of the blood-brain barrier,parenchymal granuloma formation,involvement of various local and systemic immunocytes.Both the clinical heterogeneity of NC and the pathologic changes it leads to are closely related to host immune response.This article reviews the immune response in relation to the clinical heterogeneity and pathologic changes of NC,influencing factors（developmental stages,size,number,location,and genetics of Taenia solium as well as the age,gender,and genetics of the host）,and mechanisms of immune response to NC.

关 键 词：脑囊虫病 临床异质性 血脑屏障 肉芽肿形成 免疫反应 综述 

分 类 号：R532.33[医药卫生—内科学]