种植体植入后牙槽骨破骨细胞的活性变化  

The activity of osteoclast in peri-implant tissues in Beagle dogs

作　　者：柳忠豪 周文娟 郝鹏杰 卢志山 孟磊 孙爱杰 

机构地区：[1]山东省烟台市口腔医院种植中心,山东烟台264008

出　　处：《上海口腔医学》2012年第5期511-514,共4页Shanghai Journal of Stomatology

基　　金：山东省自然科学基金(Y2008C43)~~

摘　　要：目的:动态观察种植体植入后不同时间段周围牙槽骨破骨细胞的数目、活性的表达变化规律。方法 :选用6只成年雄性Beagle犬作为实验动物,随机选择双侧下颌第二前磨牙及第四前磨牙共计24个牙位,分别以12个牙位作为实验组和对照组,检侧种植体植入后3、7、15、30、60和90 d种植体周围牙槽骨破骨细胞的活性变化。取犬下颌骨进行大体标本观察,拍摄X线片,取种植体周围骨组织进行HE染色,观察破骨细胞的形态学变化,并进行定量组织学分析,对照组拔牙窝的检测方法相同。采用SPSS13.0软件包对数据进行统计学分析。结果:破骨细胞的表达活性在种植体植入后第7天达到高峰,而后随时间延长逐渐降低,实验组破骨细胞的活性表达显著活跃于对照组。结论:破骨细胞性骨吸收最为活跃的时间在种植体植入后的第7天左右。PURPOSE：To observe the quantity and activity of osteoclast in peri-implant tissues dynamically. METHODS： An animal model of dental implants was established in 6 male Beagle dogs of 1-2 years old.Bone remodeling was tested at 3-,7-,15-,30-,60-and 90-day after placement of implants.The mandibular bones were taken out and the morphological changes were observed under X-ray examination.Bone tissue samples underwent HE staining. The data were analyzed with SPSS13.0 software package.RESULTS： The most prominent period of osteoclasts occurred at 7-day after placement of implants.After 7 days of implantation,the activity of osteoclast gradually decreased. CONCLUSIONS： The active stage for bone remodelling in peri-implant tissues during unloading period is about 7 days after implantation.

关 键 词：牙种植 非负荷期 破骨细胞 骨改建 

分 类 号：R783.6[医药卫生—口腔医学]