高脂血症、糖尿病与年龄相关性白内障的关系  

Association between hyperlipidemia,diabetes and age-related cataract

作　　者：姜腾轩[1] 翟淑娜[1] 闫佳[1] 李岩[1] 卢智泉[1] 

机构地区：[1]辽宁医学院流行病学教研室,中国辽宁省锦州市121001

出　　处：《国际眼科杂志》2012年第11期2098-2101,共4页International Eye Science

基　　金：中国辽宁省教育厅科学技术研究基金资助项目(No.2008424)~~

摘　　要：目的:探讨中老年人群高脂血症、糖尿病与年龄相关性白内障(age-related cataract,ARC)的关系。方法:采用以医院为基础的病例对照研究方法,病例组由年龄45～85岁的360例ARC患者所组成;对照为与病例同期入住相同医院,未患与ARC有关眼病的360例患者,对照组与病例采取1:1匹配方式。采用自行设计的调查表对研究对象进行调查,内容包括人口学特征、生活方式、疾病既往史等,同时收集研究对象的临床生化检测资料,包括空腹血糖、高密度脂蛋白胆固醇(HDL-C)、总胆固醇(TC)及甘油三酯(TG)等。采用多因素Logistic回归分析,估计研究因素与ARC关联的比值比(OR)及其相应的95%可信区间(CI)。结果:调整了年龄和性别因素后,高脂血症、高脂血症病程、TC及TG与发生ARC的危险性无关(P>0.05),仅HDL-C下降与发生ARC的危险性升高有关(OR=1.519,95%CI:1.093～2.110,P=0.013)。在调整了多种潜在性混杂因素后,经多因素Logistic回归分析的结果显示,空腹血糖受损的研究对象发生ARC的危险性升高了73%(OR=1.734,95%CI:1.102～2.725,P<0.001),而已确诊的糖尿病患者发生ARC的危险性升高了94%(OR=1.938,95%CI:1.293～2.906,P<0.001)。糖尿病病程也与ARC呈显著性正相关,糖尿病病程<10a和10～19a的病例发生ARC的危险性分别是未患糖尿病对照的2倍(OR=2.347,95%CI:1.502～3.752,P=0.010)和3倍(OR=2.683,95%CI:1.267～5.683,P<0.001)。结论:HDL-C下降及糖尿病可使中老年人群发生ARC的危险性增加。AIM：To investigate the association between hyperlipidemia and diabetes with the risk of age-related cataract（ARC） in middle-aged and elderly men.METHODS：A hospital-based case control study was conducted.Cases（n=360） were patients with cataract 45-85 years old.Controls（n=360） were patients with diseases that not related with cataract and were admitted to the same hospital.Cases and controls were matched with 1：1.All subjects were interviewed using a structured interviewer-administrated questionnaire.Questionnaire was designed to cover demographic data,lifestyle,previous diseases history,also collected the clinical biochemical examination data,including fasting blood glucose,high density lipoprotein-cholesterol（HDL-C）,total cholesterol（TC）,triglyceride（TG）.The odds ratios（OR） and corresponding 95% confidence intervals（CI） of ARC were estimated using multiple logistic regression models.RESULTS：：After adjusted for age and gender,hyperlipidemia,hyperlipidemia duration,TC,and TG had no relation with the risk of ARC（P0.05）,though only declining levels of the HDL-C were associated with higher risk of ARC（OR =1.519,95% CI：1.093-2.110,P=0.013）.After adjusting for multiple potential confounders,fasting glucose impaired subjects was positively related with ARC（OR=1.734,95% CI：1.102-2.725,P0.001）,however,those cases with diabetes had a larger risk than controls（OR=1.938,95% CI：1.293-2.906,P0.001） in multivariate logistic regression analysis.Diabetes duration was also positively related with ARC.The risk of ARC less than 10 years and 10 to 19 years in duration significantly increased（OR=2.374;95%CI：1.502-3.752,P0.001 and OR=2.683;95% CI：1.267-5.683,P=0.010 respectively）.CONCLUSION：This study indicates that the HDL-C,diabetes are associated with an increased risk for ARC in middle-aged and elderly men.

关 键 词：年龄相关白内障 高脂血症 糖尿病 病例对照研究 

分 类 号：R776.1[医药卫生—眼科]