绒癌细胞β-hCG含量与病理形态的关系  

β-hCG Level within Choriocarcinoma Cells Patho-morphology

作　　者：熊世钢[1] 姚敏[1] 王萍[1] 张世馥 谢群 

机构地区：[1]蚌埠医学院病理学教研室

出　　处：《安徽医科大学学报》1990年第3期168-171,共4页Acta Universitatis Medicinalis Anhui

摘　　要：本文用免疫组化和图象分析的方法,从病理形态结合功能代谢的角度观察分析了51例子宫绒毛膜癌。发现-hCG含量高者,其细胞多以合体滋养细胞(ST)为主,且呈丛状生长并摸拟胎盘绒毛排列,癌细胞多同步发育;反之,STf-hCG含量低者,癌细胞则多以细胞滋养细胞和(或)中间型滋养细胞为主且呈片块状,细胞排列紊乱,发育不同步(P<0.05～0.01)。本结果提示,绒癌的病理形态与其功能代谢间有着十分微妙的关系。作者认为对绒癌等病理形态与生物学行为相关性较差的肿瘤,应引入机能形态学和动力形态学的观点。From the aspects of patho-morphology and functional metabolism, 51 cases of choriocarcinoma were studied by immunohistochemical and image-analytical methods. It was found that those having a higher level of 3-hCG were associated with. a predominance of syncytiotrophoblast (ST), a plexiform of nidi, a chorion-line arrange of tumor cells and the synchronous development of cytoplasm with nuclei, Those having a lower level of β-hCG, conversely, had a predomi nance of cytotrophoblast(CT)and/or Intermediate cells,with a mass of nidi, a irregular arrange of the cells and non-synchronous develop ment of both cytoplasm with nuclei and CT with ST. It was suggested that there be a subtle correlation between the patho-morphology of choriocarcinoma and the function, and the combination of function withmorphology plays an important role in predicting the biologic behavior and the nature of choriocarcinoma.

关 键 词：绒毛膜癌 病理学 免疫组化 

分 类 号：R737.33[医药卫生—肿瘤]