白细胞介素-18、白细胞介素-1β、和肽素与急性脑梗死的相关性分析  

Correlation analysis between interleukin-18,interleukin-1β,copeptin and acute cerebral infarction

作　　者：赵焱[1] 马翔凌[1] 张艳梅[1] 陈向东[1] 刘斌[1] 甄谨[1] 冯银玲[1] 

机构地区：[1]内蒙古自治区医院神经内科,呼和浩特010050

出　　处：《中国医师进修杂志》2012年第31期4-6,共3页Chinese Journal of Postgraduates of Medicine

基　　金：内蒙古自治区自然科学基金（2009MS1126）

摘　　要：目的探讨血清白细胞介素（IL）-18、IL-1β、和肽素水平在急性脑梗死（ACI）中的动态变化，并分析其与ACI病情严重程度之间的关系。方法83例ACI患者在发病后24h内人院，分别在入院后（发病后）第1、3、7天抽取空腹静脉血，采用双抗体夹心酶联免疫吸附法检测血清IL-18、IL-1β、和肽素水平，采用欧洲卒中量表（ESS）评估ACI病情严重程度；同时选择32例健康体检者进行对照比较。结果ACI患者发病后第1、3、7天血清IL-18水平分别为（131．30±31．62）、（168．30±28．12）、（141．26±24．23）ng／L，IL-1β水平分别为（0．35±0．04）、（0．82±0．10）、（0．52±0．21）μg／L，和肽素水平分别为（3．64±0．26）、（4．18±0．53）、（3．26±2．41）μg,／L，各指标不同时间比较差异均有统计学意义（P〈0．05），且均明显高于健康体检者[（119．12±27．42）ng／L、（0．21±0．08）μg／L、（2．63±0．23）μg／L]（P〈0．05）。单因素Logistic回归分析结果显示，年龄、和肽素、IL-18、IL-1β、ESS评分为ACI患者病情严重程度的影响因素（P〈0．05）；受试者工作特征曲线分析结果显示，IL-18对ACI患者病情严重程度的评估价值与年龄、和肽素、IL-1β、ESS评分的评估价值比较差异无统计学意义（P〉0．05）。结论血清IL-18、IL-1β、和肽素水平在ACI发病后升高，说明应激刺激后启动炎性免疫因子和神经内分泌因子参与了ACI的发生、发展过程。血清IL-18、IL-1β、和肽素水平可作为ACI病情严重程度的有效判断指标。Objective To investigate the dynamic changes of serum interleukin （IL）-18, IL-1β and copeptin in acute cerebral infarction （ACI）, and analyze the relationship with the serious degree of ACI. Methods The levels of serum IL-18,IL-1β and copeptin were measured by Double-antibody sanduieb enzyme-linked immunosorbent assay （ELISA） in 83 patients with ACI who were admitted to the hospital within 24 h, and neurological impairment were evaluated by European stroke scale （ESS） at the 1 st, 3rd and 7th day respectively after hospitalization. At the same time,the patients with ACI were compared with 32 normal adults. Results The levels of serum IL-18,IL-1 β and copeptin at the 1st, 3rd and 7th day after hospitalization were （ 131.30 ±31.62）, （ 168.30± 28.12）, （ 141.26±24.23） ng/L, （0.35 ±0.04）, （0.82 ± 0.10 ）, （0.52 ± 0.21 ） μg/L, and （3.64 ± 0.26 ）, （4.18 ±0.53 ）, （3.26± 2.41 ） μ g/L respectively. There were significant differences among different times respectively （P 〈 0.05 ）, furthermore they were higher than those in normal adults [ （ 119.12 ± 27.42 ） ng/L, （ 0.21 ±0.08 ） μ g/L, （ 2.63±0.23 ） μg/L ] （P 〈 0.05 ）. Univariate Logistic regression analysis showed that age, copeptin, IL-18, IL- 1β and ESS score was the influencing factor in the serious degree of ACI. There was no significant difference in assessing the serious degree of ACI by receiver operating characteristic （ROC） curve between IL-18 and age,copeptin,IL-1β, ESS score （P〉 0.05）. Conclusions The serum levels of IL-18 ,IL-1β and copeptin are increasing after ACI,indicating that the inflammatory and immune factors may be involved in the development process of ACI. The serum levels of IL-18, IL-1β and copeptin can reflect the serious degree of ACI.

关 键 词：白细胞介素1β白细胞介素18 和肽素 

分 类 号：R743.3[医药卫生—神经病学与精神病学]