ROC曲线分析2型糖尿病合并脂肪肝患者诊断代谢综合征的预测意义  

Relationship between fatty liver and metabolic syndrome in T2DM patients by ROC curve

作　　者：刘佳[1] 赵伟[1] 刘倩[1] 李维[1] 张宏[1] 

机构地区：[1]天津医科大学代谢病医院肥胖代谢科,卫生部及天津市激素与发育重点实验室 ,300070

出　　处：《中国实用医刊》2012年第22期3-5,共3页Chinese Journal of Practical Medicine

摘　　要：目的研究2型糖尿病患者合并脂肪肝对代谢综合征的诊断意义。方法回顾性分析320例2型糖尿病患者的临床资料，按是否合并代谢综合征分成两组。比较两组患者体质量指数、血压、血脂、肝功能和脂肪肝的患病率，应用受试者工作特征（ROC）曲线分析脂肪肝对诊断代谢综合征的预测意义。结果本研究人群脂肪肝的检出率为44．1％，合并代谢综合征患者的体质量指数、舒张压、血清三酰甘油、γ-谷氨酰转移酶水平及脂肪肝的患病率明显高于非代谢综合征组（P〈0．05）；相关性分析代谢综合征与脂肪肝（r=0．44，P〈0．01）和血清叫．谷氨酰转移酶水平（r=0．19，P〈0．01）明显相关；绘制ROC曲线，脂肪肝的曲线下面积为0．72（P〈0．01），介于体质量指数、血清三酰甘油和血压、高密度脂蛋白胆固醇之间。结论2型糖尿病患者合并脂肪肝对诊断代谢综合征有预测意义。Objective To study the relationship between non-alcoholic fatty liver disease （NAFLD） and metabolic disease（MS） in type 2 diabetes mellitus （T2DM）. Methods Three hundred and twenty eases of T2DM patients were divided into MS group and Non-MS group. Body mass index （BMI）, blood pressure, blood lipids, liver function and the morbidity of NAFLD were evaluated. The relation between NAFLD and MS was analyzed by receiver operating characteristic （ROC） curve. Re- suits The detection rate of NAFLD was 44. 1%. MS patients had higher BMI, diastolic blood pressure, serum triglycerides（Tg）, gamma-glutamyltransferase（GGT） and the morbidity of NAFLD than Non-MS group （P 〈 0. 05）. Pearson relative analysis demonstrated that MS was related to NAFLD （r = 0.44, P 〈 0.01 ） and serum GGT （r = 0. 19, P 〈 0.01 ）. The area under the ROC curve of NAFLD was 0.72 （P 〈 0. 01 ） , in the middle of BMI, TG and blood pressure, high-density lipoprotein cholesterol. Con- clusions Type 2 diabetes patients complicated with NAFLD are phone to have MS.

关 键 词：2型糖尿病 代谢综合征 脂肪肝 受试者工作特征曲线 

分 类 号：R575[医药卫生—消化系统] R587[医药卫生—内科学] R589[医药卫生—临床医学]