老年患者脑白质疏松程度与CAIMT、hs—CRP的相关性  

Correlation study of the degree of leukoaraiosis with CAMIT and hs-CRP in elderly patients

作　　者：王卫华[1] 张永葆[1] 徐均陶[1] 韦俊超[1] 张业敏[1] 葛伟[1] 

机构地区：[1]安徽省巢湖市第一人民医院神经内科,238000

出　　处：《中国实用医刊》2012年第22期70-72,共3页Chinese Journal of Practical Medicine

摘　　要：目的探讨老年患者脑白质疏松（LA）程度与颈动脉内中膜厚度（CAMIT）、血清高敏C-反应蛋白（hs—CRP）之间的相关性。方法选取老年LA患者81例，根据头颅MRI脑白质疏松程度分为三组：LA1级组32例，LA2级组23例，LA3级组26例。选取同期健康体检无脑白质疏松的老年人32例为对照组，分别测定各组受试者空腹血糖（FBG）、总胆固醇（CHOL）、三酰甘油（TG）、低密度脂蛋白（LDL）、高密度脂蛋白（HDL）、血尿酸（UA）、hs—CRP水平及CAIMT。结果LA1级组、2级组、3级组与对照组比较：CAIMT差异均有统计学意义（P〈O．05），LA1级组与3级组比较差异有统计学意义（P〈0．05）；LA2级组与3级组hs—CRP水平与对照组比较差异有统计学意义（P〈0．05），LA1级组与LA3级组比较差异有统计学意义（P〈0．05）；hs—CRP、CAIMT相关性分析显示CAIMT与C-反应蛋白水平呈正相关（r=0．879，P〈0．01）。结论hs—CRP介导的炎症反应及颈动脉硬化导致的慢性脑缺血可能参与了LA的发病机制：hs—CRP、CAMIT与脑白质疏松的程度密切相关。Objective To investigate the correlationship between the degree of leukoaraiosis （LA） with intima media thickness of carotid （CAMIT） and high-sensitivity C-reactive protein （hs-CRP） in elderly patients. Methods Eighty-one elderly patients with LA were divided into three groups accord- ing to the degree of leukoaraiosis detected by magnetic resonance imaging （MRI） , 32 cases were in LA level 1 group, 23 cases were in LA level 2 group, 26 cases were in LA level 3 group. Thirty-two healthy elderly people without LA were in control group. The differences were compared between the four groups in FBG, CHOL,TG, LDL, HDL, UA, hs-CRP and CAIMT. Results The CAIMT of LA patients were significantly higher than those of control group （ P 〈 O. 05 ） , there was significant difference between LA 1 level group and 3 level group （ P 〈 0.05 ） , the hs-CRP levels of LA level 1 group and level 2 group were significant different （ P 〈 0. 05 ） with controls, there were significantly difference （ P 〈 0.05 ） be- tween LA level 1 group and level 3 group. The correlation analysis showed CAIMT was positively correla- ted with hs-CRP （ r =0. 879, P 〈0. 01）. Conclusions hs-CRP and carotid atherosclerosis may playan important pole in the pathogenesis of LA, CAMIT and hs-CRP were closely correlatedwith the degree of leukoaraiosis.

关 键 词：脑白质疏松 颈动脉内中膜厚度 高敏C-反应蛋白 老年患者 

分 类 号：R74[医药卫生—神经病学与精神病学]