LAT1表达与人脑胶质瘤病理级别、增殖和血管形成的关系  

Relation between LAT1 expression and pathological grade,proliferation and angiogenesis in human brain gliomas

作　　者：甄海宁[1] 河井信行[2] 冈田真树[2] 大久保修一[2] 费舟[1] 章翔[1] 刘卫平[1] 霍军丽[1] 田宫隆[2] 

机构地区：[1]第四军医大学西京医院神经外科,陕西西安710032 [2]香川大学医学部脑神经外科

出　　处：《中华神经外科疾病研究杂志》2012年第5期427-431,共5页Chinese Journal of Neurosurgical Disease Research

基　　金：第四军医大学西京医院学科助推计划创新人才项目资助项目(XJZT08R09)

摘　　要：目的探讨大型氨基酸转运载体1(LAT1)在人脑胶质瘤组织中的表达水平及其与胶质瘤病理学特征、细胞增殖以及血管形成的关系。方法采用免疫组化方法检测LAT1、Ki-67和CD34在62例人脑胶质瘤组织中的表达,计算Ki-67标记指数(Ki-67 LI)和微血管密度(MVD)。结果LAT1在胶质瘤中高表达,其免疫阳性染色既定位于瘤细胞也定位于血管内皮;LAT1表达随胶质瘤病理级别升高而明显增强(P=0.000),在高恶性度胶质瘤中LAT1表达明显强于低恶性度胶质瘤(P=0.002);LAT1表达与胶质瘤Ki-67标记指数(P=0.003)和微血管密度(P=0.000)都存在明显正相关。结论 LAT1与胶质瘤的发生和发展关系密切,可能在胶质瘤的恶性增殖和血管形成中发挥重要作用。Objective To investigate the expression level of large-type amino acid transporter 1（LAT1）,as well as its relation with pathological features,cell proliferation and angiogenesis in human brain gliomas.MethodsExpressions of LAT1,Ki-67 and CD34 were examined by immunohistochemistry method,and Ki-67 labeling index（Ki-67 LI） and microvessel density（MVD） were measured in 62 cases of human brain gliomas.Results LAT1 was over-expressed in glioma tissues,and its immunoreactivity was located not only in tumor cells but also in vascular endothelia.LAT1 expression was enhanced significantly with glioma pathological grade ascending（P=0.000）,and it was significantly higher in malignant glioma tissues than in benign glioma tissues（P=0.002）.LAT1 expression was markedly positively correlated with both Ki-67 labeling index（P=0.003） and microvessel density（P=0.000）.Conclusion LAT1 is closely associated with formation and progression of gliomas,which may play an important role in malignant proliferation and angiogenesis of gliomas.

关 键 词：大型氨基酸转运载体1 胶质瘤 增殖 血管形成 

分 类 号：R739.41[医药卫生—肿瘤]