Sugar-fiber Imprinting to Generate Microgrooves on Polymeric Film Surfaces for Contact Guidance of Cells  

作　　者：屈泽华 丁建东 

机构地区：[1]State Key Laboratory of Molecular Engineering of Polymers,Department of Maeromolecular Science,Advanced Materials Laboratory,Fudan University,Shanghai 200433,China

出　　处：《Chinese Journal of Chemistry》2012年第10期2292-2296,共5页中国化学（英文版）

摘　　要：Anisotropic surface topography is known to induce the contact guidance of cells, and facile and biocompatible approaches of the physical modification of the pertinent matrix surfaces are thus meaningful for biomaterials. Herein, we put forward a sugar-fiber imprinting technique to generate microgrooves on hydrophobic polymers demonstrated by the poly（lactic-eo-glycolic acid） （PLGA） films. Microgrooves were conveniently generated after removing sugar fibers simply by water. The resulting locally anisotropic microgrooves were confirmed to elongate the cells cultured on the surface.Anisotropic surface topography is known to induce the contact guidance of cells, and facile and biocompatible approaches of the physical modification of the pertinent matrix surfaces are thus meaningful for biomaterials. Herein, we put forward a sugar-fiber imprinting technique to generate microgrooves on hydrophobic polymers demonstrated by the poly（lactic-eo-glycolic acid） （PLGA） films. Microgrooves were conveniently generated after removing sugar fibers simply by water. The resulting locally anisotropic microgrooves were confirmed to elongate the cells cultured on the surface.

关 键 词：polymers BIOMATERIALS surface modification contact guidance of cells poly（lactic-co-glycolic acid）（PLGA） sugar fibers 

分 类 号：TQ317[化学工程—高聚物工业] O484.41[理学—固体物理]