Direct N-Arylation of Azaheterocycles with Aryl Halides under Ligand-free Condition  

作　　者：杨奇超 王玉芳 张保集 张明杰 

机构地区：[1]Chemistry Department,School of Science,Tianjin University,Tianjin 300072,China [2]Chemistry and Pharmaceutical Engineering College,Nanyang Normal University,Nanyang,Henan 473061,China

出　　处：《Chinese Journal of Chemistry》2012年第10期2389-2393,共5页中国化学（英文版）

基　　金：This work was supported by the National Natural Science Foundation of China （No. 20802049）.

摘　　要：A simple and efficient C--N cross-coupling method of aryl halides with various heterocycles was reported, by using 10 tool% of CuI as catalyst and 1.2 equiv. Nail as base. Aryl iodides, aryl bromides and many substituted atyl chlorides could efficiently react with heterocycles, providing variety of N-arylated products in good to excellent yields. The ligand-free catalyst system was stable in air and could be readily reused.A simple and efficient C--N cross-coupling method of aryl halides with various heterocycles was reported, by using 10 tool% of CuI as catalyst and 1.2 equiv. Nail as base. Aryl iodides, aryl bromides and many substituted atyl chlorides could efficiently react with heterocycles, providing variety of N-arylated products in good to excellent yields. The ligand-free catalyst system was stable in air and could be readily reused.

关 键 词：N-ARYLATION aryl halide HETEROCYCLE CROSS-COUPLING CUI 

分 类 号：O643.36[理学—物理化学] O621.251[理学—化学]