胰腺癌血管内皮生长因子表达及与微血管生成的关系  

Expression of Vascular Endothelial Growth Factor in Pancreatic Carcinoma and its Relationship to Angiogenesis

作　　者：华鲁纯[1] 倪泉兴[1] 张群华[1] 姚琪远[1] 蔡峥嵘 钱睿哲 

机构地区：[1]上海医科大学华山医院外科,上海200040

出　　处：《上海医科大学学报》2000年第2期124-126,共3页Journal of Fudan University(Medical Science)

摘　　要：目的　探讨胰腺癌血管内皮生长因子 (VEGF)表达及与微血管生成、临床分期、病理分级的关系。方法　用免疫组织化学方法检测 30例胰腺癌组织中VEGF表达和微血管密度 (MVD)。结果　胰腺癌组织中VEGF表达阳性率 6 3.3% (19/ 30 ) ;VEGF阳性者MVD显著高于阴性者 (P <0 .0 5 ) ;Ⅲ～Ⅳ期组VEGF表达率显著高于Ⅰ～Ⅱ期组 (P <0 .0 5 ) ;VEGF表达及MVD与病理分级无关。结论　胰腺癌组织中VEGF高表达 ,VEGF使微血管大量生成 ,促进肿瘤生长、转移 ,VEGF和MVD可作为反映胰腺癌生物学行为的一个参考指标。Purpose To investigate the relationship among the expression of vascular endothelial growth factor(VEGF),angiogenesis and clinicopathologic factors in pancreatic carcinoma(PCA). Methods The expression of VEGF and microvascular density(MVD) were examined by using immunohistochemical technique in 30 cases of pancreatic carcinoma. Results The expression of VEGF in tumor tissue was found in 63.3%(19/30) of cases.MVD was significantly higher in VEGF positive tumors than in VEGF negative tumors ( P <0.05).The rate of VEGF expression in group of stage Ⅲ-Ⅳ was significantly higher than in group of stage Ⅰ-Ⅱ( P <0.05).No correlation was detected among the expression of VEGF,MVD and pathological grades of PCA. Conclusions Enhanced expression of VEGF was found in tissues of PCA.VEGF is a potent angiogenic factor and promotes growth,metastasis of PCA.VEGF expression or MVD is one of the predictors for the biological behavior of PCA.

关 键 词：胰腺肿瘤 VEGF 微血管生成 

分 类 号：R735.902[医药卫生—肿瘤]