血管内皮生长因子-C/VEGFR-3在宫颈癌及上皮内瘤样变中的表达  

作　　者：陈志琴[1] 陈海燕[1] 林美姜[1] 刘佳华[1] 

机构地区：[1]福建医科大学省立临床学院妇产科,350001

出　　处：《当代医学》2012年第31期2-4,共3页Contemporary Medicine

摘　　要：目的观察宫颈上皮内瘤样变和浸润性宫颈癌组织中血管内皮生长因子(VEGF)-C/VEGFR-3表达变化情况,分析宫颈癌发生发展过程中,淋巴血管形成的表型可能发生的时期。方法免疫组织化学S-P检测33例CINI、32例CINII、37例CINIII、30例ICC患者中VEGF-C/VEGFR-3的表达水平。结果 ICC组VEGF-C、VEGFR-3阳性率分别为86.67%、90%,明显高于CINI和CINII组,差异有统计学意义(均P<0.05),而与CINIII组(VEGF-C、VEGFR-3阳性率分别为83.78%、81.08%)相比差异无统计学意义(P>0.05);CINIII组与CINI和CINII组相比差异均有统计学意义(均P<0.05);CINI组与CINII组相比差异无统计学意义(P>0.05)。7例演进为ICC的CINIII显示VEGF-C/VEGFR-3呈强阳性表达,有5例发生盆腔淋巴结转移。结论在宫颈癌发生发展过程中,淋巴血管形成的表型可能发生在CINIII期。Objective To explore the expression of vascular endothlial growth factor（VEGF）-C/VEGFR-3 in the cervical intraepithelial neoplasia（CIN）and invasive carcinoma of cervix（ICC）,in order to analyze that a switch to the lymphangiogenic phenotype may occur in cervical carcinogenesis.Methods Immunohistochemieal technique was employed to study the expression of VEGF-C/VEGFR-3 in 33 cases with CIN I,32 cases with CIN II,37 cases with CIN III and 30 cases with ICC.Results The positive rate of VEGF-C,VEGFR-3 in ICC group was higher than that of CIN I and CIN II group,the difference was statistically significant（P0.05）,and there was no significant difference compared with CIN III group（P0.05）;there was significant difference between CIN III group and CIN I and CIN II group（P0.05）;CIN I group and CIN II group was nosignificant difference（P0.05）.VEGF-C/VEGFR-3 were strong positive in 7 cases with CINIII development to ICC,5 cases of which occured pelvic lymphatic metastasi.Conclusion A switch to the lymphangiogenic phenotype may occur at the stage of CIN III in cervical carcinogenesis.

关 键 词：宫颈上皮内瘤样变 浸润性宫颈癌 血管内皮生长因子 

分 类 号：R737.33[医药卫生—肿瘤]