雌激素受体β亚型在肿瘤中的研究进展  

Research Progress of Estrogen ReceptorβIsoforms 1-5 in Cancers

作　　者：唐和孝[1] 廖永德[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院胸外科,武汉市430030

出　　处：《中国肿瘤临床》2012年第20期1568-1571,共4页Chinese Journal of Clinical Oncology

摘　　要：雌激素不仅对人体生长、发育和器官功能维持等起重要的生理作用,而且与众多肿瘤的进展密切相关。雌激素主要通过雌激素受体(estrogen receptor,ER)发挥作用。雌激素受体β在肿瘤中的重要作用受到普遍关注,但是雌激素受体β(ERβ)的功能存在较多争议,而ERβ亚型1～5的突破性研究很可能是解释这些争议的关键点,并且ERβ1～5在肿瘤中的研究可以深化对ERβ信号通路在肿瘤进展中作用的认识。因此,本文就ERβ1～5的组织细胞分布、功能、在肿瘤中的研究进展等方面进行综述。Estrogens act by binding to and activating two estrogen receptors （ERs）： ERa and ERβ. Estrogens control many cellular processes, including the growth, differentiation, and function of the reproductive system. Recently, numerous studies reported on the functions of ERβ in tumors. However, the results of these studies remain controversial. The discovery of different isoforms （i.e., ERβ-1 to ERβ-5） is likely to explain the conflicting points-of-view. It will also increase our knowledge about the molecular basis of ERβ signaling, including the unknown physiological functions of these ERβ isoforms. Improved insights into the physiology, pathophysiology, and molecular biology of ERβ-mediated signaling may lead to tion against estrogen-related diseases. This review will provide β-1 to ERβ-5 isoforms in relation to cancer. the identification of novel targets for the effective therapeutic intervenan overview of the most recent advances in the identification of the ER

关 键 词：雌激素受体β1~5 亚型 肿瘤 

分 类 号：R730.2[医药卫生—肿瘤]