槲皮素和藜蒿对肿瘤细胞生长抑制的初步研究  

Inhibition Effects of Artemisia Selengensis Turcz and Quercetin on Colon Carcinoma Cell Growth

作　　者：王可[1,2] 周南进[2] 黄颖丽[3] 曹俊[3] 高菁 

机构地区：[1]南昌大学研究生院医学部 [2]江西省医学科学研究所生化研究室,南昌330006 [3]九江学院基础医学院生化教研室,江西九江332005 [4]江西省药物滥用监测站药物监测室,南昌330046

出　　处：《南昌大学学报（医学版）》2012年第8期10-12,15,共4页Journal of Nanchang University：Medical Sciences

摘　　要：目的研究槲皮素和藜蒿对鼠结肠癌细胞株CMT-93细胞的生长抑制作用。方法取对数生长期的鼠结肠癌细胞株CMT-93细胞进行培养、传代。采用CCK-8法观察不同浓度藜蒿、槲皮素及联合用药对鼠结肠癌细胞株CMT-93生长所起的作用。结果槲皮素、藜蒿均可抑制鼠结肠癌细胞株CMT-93细胞的生长,在一定范围内呈剂量依赖关系。槲皮素协同藜蒿可抑制鼠结肠癌细胞株CMT-93细胞的生长。结论槲皮素和藜蒿对鼠结肠癌细胞株CMT-93细胞的生长有抑制及协同抗肿瘤作用。Objective To investigate the inhibition effects of Artemisia selengensis Turcz and quercetin on the growth of colon carcinoma CMT-93 cells.Methods The murine CMT-93 cells during the logarithmic phase of growth were cultured and passaged.CMT-93 cell growth inhibition induced by Artemisia selengensis Turcz and quercetin was determined using CCK-8 method.Results Both Artemisia selengensis Turcz and quercetin inhibited the growth of CMT-93 cells in a dose-dependent manner within a certain range.In addition,Artemisia selengensis Turcz and quercetin showed a synergistic effect.Conclusion Artemisia selengensis Turcz and quercetin can inhibit the growth of CMT-93 cells and have synergistic anti-tumor effect.

关 键 词：槲皮素 藜蒿 鼠结肠癌细胞株CMT-93细胞 生长 抑制 

分 类 号：R73-36[医药卫生—肿瘤]