单胺氧化酶A基因30bp可变数目串联重复多态性与愤怒特质的关联性研究  

Association study on 30bp variable number of tandem repeat polymorphism of monoamine oxidase A gene and anger-related personality traits

作　　者：闫秀娟[1] 詹向红[1] 刘永[1] 李伟[1] 侯俊林[1] 闫国立[1] 王淑玲[2] 王友杰[1] 杨丽萍[1] 

机构地区：[1]河南中医学院,郑州450008 [2]郑州大学医学院,郑州450052

出　　处：《中华中医药杂志》2012年第11期2823-2826,共4页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家自然科学基金资助项目(No.30772686;No.30973695)~~

摘　　要：目的:探讨单胺氧化酶A(MAOA)基因启动子区30bp可变数目串联重复多态性与愤怒特质的关联性。方法:根据状态特质愤怒表达量表2(STAXI-2)特质怒得分筛选受试者,经采血、酚-氯仿法提取DNA、PCR-LDR法基因分型后,对相关数据进行统计分析。结果:共获得4种30bp重复序列的等位基因:2R、3R、4R和5R,常见等位基因是3R和4R。高、低特质怒组MAOA基因30 bp可变数目串联重复多态性常见基因型和等位基因频率分布差异无统计学意义,不同基因型个体在怒的表达与控制方面的得分差异亦无统计学意义。结论:MAOA基因30 bp可变数目串联重复多态性与国内正常大学生愤怒特质无显著相关性。Objective： To discuss the possible association between the 30bp variable number of tandem repeat polymorphism in the promoter region of the monoamine oxidase A gene（MAOA-VNTR） and anger-related personality traits.Methods： A totle of 2 864 health of college students were investigated with the state-trait anger expression inventory 2（STAXI-2）.The 30bp variable number of tandem repeat polymorphism were genotyped by Polymerase chain reaction（PCR）.The distribution frequency of genotype and allel were analyzed between the high and low trait anger group,and the anger control and expression in different genotypes were also analyzed.Results： There are four alleles of 30bp variable number of tandem repeat： 2R,3R,4R and 5R,with the most common being the 3R and 4R.There is no significant difference on distribution of common genotype and allel frequency between the high and low trait anger group.The expression of anger of the different genotype had no statistically significant difference in scores.Conclusion： There is no significant correlation between the 30bp variable number of tandem repeat polymorphism in the monoamine oxidase A gene and anger-related personality traits in Chinese health students.

关 键 词：愤怒特质 单胺氧化酶A 基因多态性 关联性 

分 类 号：R229[医药卫生—中医基础理论]