慢性高眼压兔模型经睫状体平坦部滤过术后UBM观察  

Ultrasound biomicroscopy observation on glaucoma rabbits' eyes after pars plana filtration technique

作　　者：任燕如[1] 唐由之[1] 于静[1] 张津京[1] 

机构地区：[1]中国中医科学院眼科医院,北京100040

出　　处：《中国中医眼科杂志》2012年第5期319-322,共4页China Journal of Chinese Ophthalmology

基　　金：国家自然科学基金(30472229)

摘　　要：目的观察慢性高眼压模型兔经睫状体平坦部滤过术后不同时间段的眼前节表现及切口、滤过泡、滤过通道和玻璃体的组织形态变化。方法 30只青紫蓝兔眼前房穿刺,注射0.3%的复方卡波姆溶液,制作慢性高眼压模型。造模成功后7 d行睫状体平坦部滤过术,分别于术后3 d、2周、1个月、2个月、3个月、6个月在全麻下对手术组兔眼行超声生物显微镜(ultrasound biomicroscopy,UBM)检查,动态观察前房、滤过泡、滤过道、前玻璃体。结果睫状体平坦部滤过术在术后半个月内普遍滤过泡形态较好,滤过道通畅。术后1个月至术后3个月滤泡增殖趋势出现,滤过泡趋于平坦,部分滤过道模糊,1只眼出现玻璃体牵拉。术后6个月,滤过泡形态较前局限、壁增厚,滤过道较前狭窄,部分未见明显的滤过道。结论睫状体平坦部滤过术中、术后并发症少,是一种安全的抗青光眼手术。术后远期滤过泡增殖是影响手术效果的一个因素。OBJECTIVE o investigate the reaction of anterior segment and the changes of intraocular tissue such as incision： filtering bleb：filtered aisle and vitreous body.METHODS Carbomer was injected into the 30 rabbits＇ anterior chamber to establish glaucoma model.When the IOP of Carbomer rabbits rose for a week： the rabbits were treated by pars plana filtration surgery.Observed the rabbtis＇ anterior segment： filtering bleb：filtered aisle and vitreous body with UBM under general anesthesia on the 3rd day： 2nd week： 1st month： 2nd month： 3rd month and 6th month after operation.RESULTS Half a month after operation： the shape of filtering blebs was good and the filtered aisles were open.Proliferation appeared 1 to 3 months postoperatively.Filtering blebs became flatter：part of filtered aisles were vague and one eye had vitreous extraction.Filtering blebs became limited and thicker： filtered aisles became narrow and some were not found 6 months postoperatively.CONCLUSIONS The pars plana filtration technique was a safe glaucoma surgery with fewer complications during and after operation.The proliferation of filtering blebs long term postoperatively was a factor which influenced the surgery effects.

关 键 词：睫状体平坦部滤过术 高眼压 UBM 

分 类 号：R-33[医药卫生] R775