动物模型在精神分裂症研究中的应用与进展  

Application and research progression of animal model in schizophrenia

作　　者：王晓良 崔东红[1] 粟幼嵩 

机构地区：[1]上海交通大学医学院附属精神卫生中心,上海200030

出　　处：《中国医药导报》2012年第30期23-26,共4页China Medical Herald

基　　金：国家自然科学基金(项目编号:30670755;81171266);上海市浦江人才计划项目(项目编号:10PJ1408800);上海市科技创新计划项目(项目编号:11140900400);上海市精神卫生中心院级课题(项目编号:2010-YJ-03)

摘　　要：精神分裂症是一种非常严重的精神疾病,给家庭和社会带来了沉重的负担。由于该病的研究方法与研究材料限制,精神分裂症的发生、发展机制尚不完全清楚。然而,自从动物模型引入到精神分裂症发病机制的研究工作后,人们从多个角度逐步来解释该病的发生与发展。本文将从动物的神经发育模型、药理模型、转基因模型及基因环境交互作用模型多个方向,就精神分裂症的发生机制作一综述,以期为今后该病的相关研究提供一定参考。Schizophrenia is a kind of serious mental health disease,which brings huge loading to families and society.Because of lacking of research methods and materials for the disease,the mechanism of this disease is not entirely clear until now.However,the starting and progression of schizophrenia have began to know gradually after animal model being introduced into the research.This article reviews about the mechanism of schizophrenia form the animal models such as neurodevelopment model,pharmacology model,transgene model and gene-environment interaction model,in order to supply helpful reference to relevant research in future.

关 键 词：精神分裂症 动物模型 

分 类 号：R749.3[医药卫生—神经病学与精神病学]