影响胃神经内分泌癌预后因素的分析  

Analysis of prognostic factors for gastric neuroendocrine carcinoma

作　　者：寇玉[1] 高业博[1] 付强[2] 谢建国[2] 

机构地区：[1]河南中医学院第一附属医院普外科,郑州450000 [2]河南省肿瘤医院普外科三病区,450008

出　　处：《临床肿瘤学杂志》2012年第10期915-918,共4页Chinese Clinical Oncology

摘　　要：目的探讨影响胃神经内分泌癌患者预后的因素。方法回顾性分析2006年5月至2011年7月38例经手术切除、病理学检查证实为胃神经内分泌癌患者的临床病理资料和随访情况。单因素生存分析用Kaplan-Meier法,预后多因素分析用Cox风险比例模型。结果 38例患者均获得随访,中位生存时间为25个月,1、3和5年生存率分别为71.1%、26.3%和15.8%。单因素和多因素分析均显示,病理分期、肿瘤最大直径和手术方式是影响胃神经内分泌癌预后的独立因素,而性别、年龄与预后无关。结论病理分期、肿瘤直径和手术方式是胃神经内分泌癌的预后影响因素。早期诊断和根治性手术有助于提高患者的术后生存率。Objective To investigate the prognostic factors of survival for gastric neuroendocrine carcinoma. Methods The clinieopathologieal and follow-up data of 42 patients with gastric neuroendocrine carcinoma, who were diagnosed by surgical resection and pathology from May 2006 to July 2011, were analyzed retrospectively. The survival was estimated using Kaplan-Meier method and compared using log-rank test. The effectiveness of independent factors on prognosis was determined by Cox regression multivariate analysis. Results All the 38 patients were followed up. The median survival of these 38 patients was 25months, and the overall 1-,3- and 5-year survival rates were 71.1% , 26. 3 % and 15.8% , respectively. Univariate and multivariate analysis showed that clinical stage, maximum tumor diameter and surgical procedure were independent prognostic factors of gastric neuroendocrine carcinoma,while gender and age were not significantly correlated with prognosis. Conclusion Clinical stage, maximum tumor diameter and surgical procedure are main prognostic factors for gastric neuroendocrine carcinoma. Early diagnosis and radical resection are effective ways to prolong the postoperative survival in patients with gastric neuroendocrine carcinoma.

关 键 词：胃肿瘤 神经内分泌癌 肿瘤分期 预后 

分 类 号：R735.2[医药卫生—肿瘤]