中国近视人群双眼角膜最薄点厚度和位置分析  

Evaluation of binocular minimum thickness of cornea in Chinese myopic population

作　　者：吴晓敏[1] 陈思思[1] 高蓉蓉[1] 王勤美[1] 黄锦海[1] 

机构地区：[1]温州医学院附属眼视光医院,325027

出　　处：《中华实验眼科杂志》2012年第11期1018-1021,共4页Chinese Journal Of Experimental Ophthalmology

基　　金：卫生部科技教育司卫生行业科研专项资金项目（200802114）;温州市科技局资助项目（Y20110045）;温州医学院附属眼视光医院创新课题项目（YNCX201101）

摘　　要：背景中央角膜厚度（CCT）是评估角膜健康状况、指导疾病诊治、设计角膜屈光手术方案的重要参数，但近来的研究表明角膜顶点并不是角膜最薄点，因此有必要对角膜最薄点的厚度和位置进行深入探讨。目的研究中国近视人群角膜最薄点与CCT的差值和距离以及双眼角膜最薄点的对称关系，探讨其规律及临床意义。方法采用Pentacam HR眼前节成像系统对282例564眼中国近视患者的角膜进行三维重建，以角膜顶点为中心，确定角膜最薄点的位置，分析左右眼间不同部位角膜厚度的差异、角膜顶点CCT与角膜最薄点的差异和距离以及双眼角膜最薄点之间的结构对称性。结果右眼平均CCT为（540．07±31．78）μm，左眼为（539．24±31．06）μm；右眼瞳孔中央角膜厚度（PCT）平均为（540．25±30．75）μm，左眼为（539．48±31．00）μm；右眼最小角膜厚度（MCT）平均值为（537．87±30．91）μm，左眼为（536．35±31．24）μm，除PCT外，双眼间CCT、MCT的差异均有统计学意义（CCT：P=0．046；PCT：P=0．065；MCT：P=0．000）。双眼间CCT、PCT、MCT值均呈线性正相关（r=0．97、0．97、0．98，P〈0．01）。Bland—Altman图分析显示，双眼的角膜厚度具有良好的一致性。角膜最薄点距离角膜顶点的距离右眼为（0．50±0．21）mm，左眼为（0．56±0．22）mm，双眼角膜最薄点的位置差异有统计学意义（P=0．000）；右眼CCT与MCT间的差值为（2．20±1．74）μm，左眼为（2．88±1．75）μm，左右眼间比较差异有统计学意义（P=0．000）。双眼角膜最薄点的位置趋向于垂直轴对称。右眼角膜最薄点位置与按垂直轴对称转化后的左眼角膜最薄点位置平均距离为（0．29±0．17）mm，角度为（28．28±28．21）°。结论本研究为中国近视人群角膜最薄点的厚度和位置提供了参考数据。双眼的CCT和MCT具有差异性，角膜最薄Background Central corneal thickness （CCT）is an important parameter to evaluate corneal healthy status and is crucial for surgical planning. However, clinical study found that the center of cornea does not correspond to the thinnest point of cornea. Thus,it is essential to characterize the minimum corneal thickness（MCT） and its location. Objective Present study was to determine the thickness and location of MCT and its relationship to the fellow eye using Pentacam High Resolution technique. Methods The 564 eyes from 282 Chinese myopic patients were reviewed in this study. The CCT, MCT,pupillary central corneal thickness （PCT）and x-y coordinate of thinnest point were bilaterally measured. Written informed consent was obtained prior to the ocular biomedical measurement. Results CCT was （540.07±31.78 ） μm in the right eyes and （539.24±31.06） μm in the left eyes; PCT was （540.25±30.75）μm in the right eyes and （539.48±31.00）μm in the left eyes. MCT was （537.87±31.91）μm in the right eyes and （536.35±31.24）μm in the left eyes, showing significant differences in all the parameters between the right eyes and left eyes expect for PCT（ CCT ： P = 0. 046 ; PCT ： P = 0. 065 ; MCT ： P = 0. 000 ）. The CCT, PCT and MCT were significantly correlated between the right eyes and left eyes （r = 0.97,0.97,0.98, P〈 0.01 ）. Bland-Aitman plot showed a good consistence between the both eyes. The mean distance from the center was （0.50±0.21） mm in the right eyes and （0.56±0.22） mm in the left eyes,showing a significant difference（P= 0. 000）. The difference between CCT and MCT was approximately （2.20±1.74）μm in the right eyes and （2.88±1.75） μm in the left eyes. The location of MCT in both the right eyes and left eyes tended to symmetry along the vertical midline. The distance between the R （ x, y） to transformed L （ x, y） was （ 0.29±0. 17 ） mm and the angular distance was （28.28±28.21）degree. Conclusions This study offers a range of M

关 键 词：生物测量 中央角膜厚度 瞳孔中央角膜厚度 最小角膜厚度值 角膜最薄点位置 对称性 

分 类 号：R779.6[医药卫生—眼科]