视网膜静脉阻塞动物模型制作的研究进展  

Current progress in research on animal model of retinal vein occlusion

作　　者：袁子茗(综述)[1] 吴强(审校)[1] 

机构地区：[1]上海交通大学附属上海市第六人民医院眼科,200233

出　　处：《中华实验眼科杂志》2012年第11期1044-1047,共4页Chinese Journal Of Experimental Ophthalmology

基　　金：国家863计划项目（YG2009ZD203）

摘　　要：视网膜静脉阻塞（RVO）常因黄斑水肿和新生血管性青光眼等严重并发症导致视力下降甚至失明，是仅次于糖尿病视网膜病变的第二位致盲性视网膜血管疾病，是临床诊断和治疗的难点之一。研究表明，本病系多因素、多环节致病，尽管随着医学基础研究和实验技术的发展，对RVO的研究不断深入，但目前其发病机制尚未完全明确，治疗效果尚不肯定。多年来，国内外学者在RVO的病因学、病理学和治疗学等方面建立了多种动物模型。就各种不同模型的制作方法进行归纳和比较，探讨其病理改变的特点，为研究者根据不同研究目的选择合适的动物模型及探讨新的治疗手段提供参考依据。Retinal vein occlusion（RVO） is a common retinal vascular disorder that frequently leads to severe vision loss and even blindness due to its complications, such as macular edema and neovascular glaucoma. It is the second leading cause of vascular eye disease behind only diabetic retinopathy. Currently there still is no definite efficacy in treatment for this disease. Researches showed that this disease is a multi-factor and link pathogenic process. Animal models could be potentially of helpful for researching the etiology, pathology and developing new treatments. This paper summarizes the different manufacture methods of the animal models, discusses the pathological changes and chooses the appropriate animal models for different research purposes and offers a good experimental basis to develop new treatments.

关 键 词：视网膜静脉阻塞 动物模型 方法学 

分 类 号：R-332[医药卫生]