Barrett食管组织HIF-1α、mtP53、IMP3蛋白表达及意义  

The expression and clinical significance of HIF-1α,mtP53 and IMP3 in Barrett′s esophagus

作　　者：丁光荣[1] 张俊文[1] 

机构地区：[1]重庆医科大学附属第一医院消化内科,400016

出　　处：《重庆医学》2012年第31期3289-3290,F0003,共3页Chongqing medicine

摘　　要：目的观察缺氧诱导因子-1α(HIF-1α)及mtP53、IMP3蛋白在Barrett食管中的表达情况,分析HIF-1α及mtP53、IMP3在Barrett食管发生、发展中的意义。方法取100例Barrett食管胃镜标本进行免疫组织化学分析HIF-1α、mtP53、IMP3蛋白的含量,并与50例反流性食管炎组织比较。结果与反流性食管炎组比较,Barrett食管组HIF-1α、mtP53、IMP3蛋白表达均明显增强(P<0.05),HIF-1α、mtP53、IMP3三者的表达呈正相关(均P<0.01)。结论 HIF-1α、mtP53、IMP3在Barrett食管的发生、发展中起着很大的作用,有可能是Barrett食管发生及恶变的机制之一。Objective To observe the expression of hypoxia-inducible factor-1α（HIF-1α）, mtP53, IMP3 protein in Barrett＇s esophagus tissue,and to analyze their significance. Methods The expression of HIF-1α,mtP53 and IMP3 in 100 patients with Bar- rett＇s esophagus gastroscopy specimens was detected with immunohistochemical method. Then compared with 50 cases of the Re- flux esophagitis tissue. Results Compared with the Reflux esophagitis group,the expressions of HIF-1α,mtP53 and IMP3 protein were significantly increased in the Barrett＇s esophagus group（P〈0.05）. The expression of HIF-1α,mtP53 and IMP3 protein was also being related（all P〈0.01）. Conclusion In the occurrence and development of Barrett＇s esophagus,HIF-1α and mtP53,IMP3 probably play a big role,There may be one of the mechanisms of deterioration and the origin of Barrett＇s esophagus.

关 键 词：BARRETT食管 免疫组织化学 缺氧诱导因子-1Α MTP53 IMP3 

分 类 号：R571[医药卫生—消化系统] R735.1[医药卫生—内科学]