转化生长因子-β受体Ⅲ在胶质瘤组织中的表达及意义  

Expression and significance of TβRⅢ in tissue of human glioma

作　　者：张述升[1] 张飚[2] 王金环[2] 阎晓玲[2] 王雷波[2] 孔繁明[2] 唐帆[2] 马苹[2] 

机构地区：[1]天津医科大学研究生院,天津300070 [2]天津市环湖医院

出　　处：《山东医药》2012年第39期32-34,共3页Shandong Medical Journal

基　　金：天津市应用基础及前沿技术研究计划(11JCYBJC12100)

摘　　要：目的探讨转化生长因子-β受体Ⅲ(TβRⅢ)在胶质瘤发生发展中的作用。方法采用免疫组化法检测TβRⅢ在3例正常脑组织、13例低级别(Ⅰ、Ⅱ级)胶质瘤和27例高级别(Ⅲ、Ⅳ级)胶质瘤中的表达,Western Blot法进一步验证各级别不同病理类型中TβRⅢ表达。结果正常脑组织中TβRⅢ阳性表达率为100%(3/3),低级别胶质瘤阳性表达率为84.6%(11/13),高级别胶质瘤阳性表达率为48.1%(13/27),高、低级别间比较,P<0.05;Ⅱ、Ⅲ级肿瘤中,星形细胞瘤和含少突成分的胶质瘤间TβRⅢ的表达无显著差异。结论高级别胶质瘤中TβRⅢ表达降低;TβRⅢ可能参与了胶质瘤的恶变过程,其低表达可促进肿瘤的侵袭和迁移。Objective To investigate the roles of transforming growth factor-β receptor m （TβRⅢ） in the occurrence and development of human glioma. Methods Immunohistochemistry and western blot were used to detect the differential expression of TβRⅢ in 3 normal brain tissues, 13 low-grade gliomas and 27 high-grade gliomas. Results TβRⅢ in 3 normal brain tissues all presented positive expression, which was 84.6% in 13 low-grade gliomas and 48.1% in 27 high- grade gliomas （P 〈 0.05）. However, there was no significance differential expression between astrocytoma and glioma with oligodendroglioma in Ⅱ and Ⅲ grade. Conclusion The low expression of TβRⅢ in high-grade gliomas may have important roles in the neoplastic processes by promoting the invasion and migration of glioma.

关 键 词：神经胶质瘤 受体 转化生长因子β免疫组织化学 印迹法 蛋白质 

分 类 号：R739.41[医药卫生—肿瘤]