酚取代双膦酸酯Schiff碱的合成及抗癌活性研究  

Studies on Synthesis and Antitumor Activity of Phenol Substituted Bisphosphonate Schiff Base

作　　者：谢雨礼[1] 宋琳[1] 朱勤 谢毓元 

机构地区：[1]中国科学院上海药物研究所,上海200031

出　　处：《中国药物化学杂志》2000年第2期88-91,共4页Chinese Journal of Medicinal Chemistry

摘　　要：设计合成了 11个含有Schiff碱双键的酚取代双膦酸酯类化合物 .对小鼠白血病细胞P388、人肺腺癌细胞A 5 49的体外抗癌活性实验表明 :目标分子中酚羟基的位置对化合物的活性有着重要影响 ,当酚羟基位于Schiff碱双键的邻位时 。In searching of effective new antitumor drugs,eleven phenol substituted bisphosphonates with the structure of the Schiff base were synthesized.Their antitumor activities on P388 cells and A 549 cells in vitro were tested.Preliminary results showed that the position of the phenol hydroxyl group had important effect on the antitumor activity,compounds with the phenol hydroxyl group next to the double bond of the Schiff bases seem more effective than others.

关 键 词：酚取代双膦酸酯 SCHIFF碱 体外抗癌活性 酚羟基\ 

分 类 号：R914[医药卫生—药物化学]