肺癌MRI与癌细胞核DNA含量及S期分数的相关性  

Correlations of MRI,DNA Contents of Nucleaus and S - phase Fraction of Lung Cancer

作　　者：许冬明[1] 陈九如[1] 杨振燕 汤如勇 詹松华 周敏华 李日乐 

机构地区：[1]上海市闸北区中心医院,200070 [2]甘泉医院放射科 [3]上海市闸北区中心医院病理科

出　　处：《中国医学计算机成像杂志》2000年第3期168-171,共4页Chinese Computed Medical Imaging

摘　　要：目的：探讨肺癌ＭＲＩ信号及形态特征与ＤＮＡ倍体的关系。材料和方法：２６例原发性支气管肺癌患者，术前用Ｒｅｓｏｎｅｘ ０．３８Ｔ磁共振成像仪行冠状面及横断面成像（ＳＥ Ｔ１ＷＩ和ＧＲ），增强后行横断面ＳＥ Ｔ１ＷＩ。术后肺癌标本用细胞图像分析仪，测定每例患者的ＤＮＡ含量及Ｓ期分数（ＳＰＦ）。结果：未增强Ｔ１ＷＩ异倍体肿瘤信号强度比显著大于二倍体肿瘤的信号强度比。异倍体肿瘤的ＳＰＦ值也显著大于二倍体肿瘤，ＭＲＩ形态特征（大小、分叶、毛刺、坏死）不能反映ＤＮＡ指数和ＳＰＦ。结论：ＭＲＩ信号强度比在一定程度上可反映肿瘤细胞的ＤＮＡ含量，信号强度高的肺癌细胞较信号强度低者ＤＮＡ含量高。Purpose: To explore the correlations of MRI, DNA contents and S - phase fraction (SPF) of lung cancer. Materials and Methods: Twenty six cases of lung cancer proved by surgery and pathology were examined with a 0. 38T MR system before operation. The pulse sequences includes SE T1 WI, gradient echo (GE) and Gd - DTPA - enhanced SE T1 WI sequences. DNA content was measured by an imaging analyzer (ICM - 100) and the SPF percentage was calculated. Results: Signal intensity ratios of lesion on unenhanced SE T1WI and SPF percentage were significantly smaller in diploid lesions than those in aneuploid lesions.Morphological characteristics of lung cancer on MRI couldn't reveal its DNA index and SPF. Conclusion: MRI signal - intensity ratios can reflect DNA ploidy in a certain degree. So, it can indirectly reflect the malignant biological behavior of lung cancer.

关 键 词：肺癌 MRI 信号强度 DNA含量 S期分数 

分 类 号：R734.2[医药卫生—肿瘤]