血管紧张素原、血管紧张素转换酶基因多态性与脑卒中相关性研究  

Association of the Polymorphism of Angiotensinogen and Angiotensin Converting Enzyme Genes with Cerebral Strokes

作　　者：苏业璞[1] 国雪[1] 胡爱祥[1] 李玲[1] 王建军[1] 张冬会[1] 张卫红[1] 高立平[1] 

机构地区：[1]河北省人民医院临床医学研究中心,石家庄050071

出　　处：《中国神经免疫学和神经病学杂志》2000年第2期105-110,共6页Chinese Journal of Neuroimmunology and Neurology

摘　　要：目的　探讨血管紧张素原基因 (AGT)的M2 35T基因多态性、血管紧张素转换酶 (ACE)基因的插入 (I) /缺失 (D)多态性与中国汉族人脑卒中发病的相关性。方法　采用PCR法和PCR RFLR法检测 10 0例脑卒中患者 (脑梗死患者 72例 ,脑出血患者 2 8例 )以及 10 0例正常人ACE(I/D)和AGT(M2 35T)的基因多态性。结果　在脑卒中患者中ACE的纯合插入 (I)基因型和I等位基因频率增加 (x2 =4 17,P =0 0 4 1) ,AGT基因的 2 35TT基因型和T等位基因频率明显增加 (x2 =2 6 79,P <0 0 0 1)。结论　同期监测AGT及ACE基因多态性是一项对急性脑血管病风险因素分子水平的检测方法 ,这对筛选脑卒中高危人群并早期采取干预对策 ,防治脑卒中有一定意义。Objective To investigate the association of the M235T polymorphism of the angiotensinogen (AGT) gene,the insertion (I)/deletion (D) polymorphism of the angiotensin converting enzyme gene and cerebral strokes in Chinese.Methods The PCR RFLR was used to test the M235T polymorphism of AGT and the D/I polymorphism of ACE genes of 100 cerebral stroke patients (72 patients with cerebral infarction,28 patients with cerebral hemorrhage) and 100 normal people. Results Frequency of the homozygous insertion genotype and I allele of ACE increase( x 2=4 17, P =0 041),while the 235TT genotype and T allele of AGT gene also increased significantly( x 2=26 79, P <0 001).Conclusion Contemporary test for the polymorphism of AGT and ACE genes is a method to evaluate the risk factors for acute cerebrovascular diseases at molecular level,which is very important for selecting high risk population of cerebral strokes and taking measures for their protection and therapy.

关 键 词：脑卒中 基因多态性 血管紧张素原 ACE 

分 类 号：R743.302[医药卫生—神经病学与精神病学]