中国汉族人群不同性别和年龄血脂水平与肝脂肪酶基因C480T位点相关性研究  

Correlation of LIPC CA80T （rs1800588） polymorphism with lipid metabolism in Han Chinese population

作　　者：谭晓华[1] 狄春红[1] 王保东[3] 孟强[1] 黄仙红[1,2] 兰满[1] 杨磊[1] 

机构地区：[1]杭州师范大学健康管理学院预防医学系,310036 [2]杭州师范大学健康管理学院卫生事业管理系,310036 [3]石河子大学医学院预防医学系

出　　处：《中华检验医学杂志》2012年第10期905-911,共7页Chinese Journal of Laboratory Medicine

基　　金：杭州市科技发展计划资助项目（20090233T07）

摘　　要：目的研究不同年龄、性别汉族人群血脂水平及血脂异常发病风险与肝脂肪酶基因（LIPC）C480T（rsl800588）位点的相关性。方法全自动生化分析仪检测2420名成人汉族健康体检人群（男1527名，女893名）空腹血脂水平；MALDI—TOFMS技术检测LIPCrsl800588位点基因型。按年龄≤44岁，45～59岁和≥60岁分为青年（男241名，女201名）、中年（男性652名，女性360名）、老年（男性634名，女性332名）3个年龄组。采用单因素方差分析同性别各年龄组内不同基因型对4项血脂指标的影响，采用二分类Logistic回归比较各型血脂异常发病风险的大小。结果LIPCrsl800588位点T等位基因在中国汉族人群中的频率为39．4％。各年龄组男女性血脂指标有较大差异。与CC基因型比较，男性中年组和老年组的CT和1Tr基因型有更高的HDL—C水平，老年组rrr基因型人群有更高的TC水平（P〈0．05）；女性青年组CT基因型有更高的TC水平，CT和1-r基因型有更高的HDL—C水平，中年组的CT和1Tr基因型人群有更高的TC和TG水平，CT基因型有更高的HDL—C水平，老年组1Tr基因型有更高的HDL—C水平。与CC基因型比较，男性老年组，IT基因型混合型高脂血症和高TC血症发病风险分别增加2．318倍（P=0．004）和2．571倍（P〈0．001），但低HDL—C血症发病风险降低1．908倍（P=0．029）；女性中年组CT和1Tr基因型高TC血症发病风险是CC基因型的1．688倍（P=0．036）和2．099倍（P=0．040），TT基因型高TG血症和混合型高脂血症发病风险分别是CC基因型的2．060倍（P=0．038）和2．381倍（P=0．019）。结论LIPCrsl800588位点与中国汉族人群的血脂水平高脂血症发病风险的相关性有性别和年龄的差异，对男性老年组和女性中年组人群的血脂水平和血脂异常发病风险有较大的影响。该位点T等位基因是高脂血症的危险因素。Objective To investigate the association of the LIPC-CA80T （rs1800588） and lipid levels and dyslipidemia in different age-and-sex groups in Han Chinese population. Methods The serum TC, TG, LDL-C and HDL-C were detected by automatic biochemical analyzer in 2420 health adults （ 1527 men and 893 women）. The genotypes of rs1800588 were detected by MALDI-TOF MS. According to the age difference （ ≤44, 45 -59 and ≥60-year-old）, the total samples were divided to young （241 men and 201 women）, middle-aged （652 men and 360 women） and older （634 men and 332 women） groups. The effects of genotypes on 4 serum lipid indicators in each age-and-gender group were analyzed by one way analysis of variance （ANOVA）, and the odd risk of genotypes on dyslipidemia was estimated by binary Logistic regression analysis. The P value less than 0.05 was considered statistically significant. Results The frequeuce of allele T for LIPC rs1800588 in this population is 39. 4%. In each age group the lipid parameters are quite different between males and females. Compared with those with CC genotype, middle-aged and elder men with CT or TT genotype have higher TC and HDL-C levels, and elder men with TY genotype also have higher TC level ; young women bearing CT genotype have higher TC level, and the CT and TY genotypes have higher HDL-C levels, middle aged women with CT or TT genotype have higher TC and TG levels, and CT genotype also have higher HDL-C level, the elder women with TT genotype have higher HDL-C level. Compared with those CC genotype individuals, the risk for mixed hyperlipidemia and hypercholesterolemia increases 2. 318 folds （P =0. 004） and 2. 571 folds （P 〈0. 001 ） respectively, while the risk for low HDL- C decreases 1.908 folds （P = 0.029 ） for TT genotypes individuals among elder males; the hypercholesterolemia risk increase 1. 688 （ P = 0. 036 ） and 2. 099 times （ P = 0. 040 ） in CT and TT genotypes respectively, and the risks for hypertriglyceridemia and mixed hyperlipidemi

关 键 词：脂肪酶 血脂异常 基因型 

分 类 号：R440[医药卫生—诊断学]