胃食管接合部癌组织中MIF的表达  

The expression of macrophage migration inhibitory factor in carcinoma of gastro-esophageal junction tissue

作　　者：郭豫兰[1] 赵劲松[2] 廖克龙[3] 杨康[3] 

机构地区：[1]武警四川总队乐山医院消化内科,四川乐山614000 [2]解放军42医院胸外科,四川夹江614100 [3]第三军医大学西南医院胸心外科,重庆400038

出　　处：《现代肿瘤医学》2012年第11期2309-2311,共3页Journal of Modern Oncology

摘　　要：目的:研究巨噬细胞移动抑制因子(MIF)在胃食管接合部癌组织中的表达及意义。方法:免疫组化检测40例胃食管接合部癌组织中MIF蛋白表达水平,分析与临床病理的相关性。结果:MIF蛋白在胃食管接合部癌组织中存在异常的高水平表达,与癌细胞的分化程度、肿瘤TNM分期密切相关。结论:MIF可能参与了胃食管接合部癌的发病机制,可以作为早期诊断、预测预后的潜在的指标之一。Objective：To explore the expression of macrophage migration inhibitory factor（MIF） in carcinoma of gastro-esophageal junction.Methods：To examine the expression level of MIF in forty patients with carcinoma of gastro-esophageal junction by immunohistochemistry staining,and analyze the clinical pathology significance.Results：MIF was overexpressed in carcinoma of gastro-esophageal junction specimens,the expression of MIF closely correlated with tumor differentiation and the tumor TNM staging.Conclusion：MIF contributed to the pathogenesis of carcinoma of gastro-esophageal junction,and MIF can be conductd as one potential index to pretest the prognosis and early diagnosis of carcinoma of gastro-esophageal junction.

关 键 词：巨噬细胞移动抑制因子 免疫组织化学 胃食管接合部癌 

分 类 号：R735.1[医药卫生—肿瘤] R735.2[医药卫生—临床医学]