膀胱部分切除术联合化疗治疗肌层浸润性膀胱癌的临床疗效分析  

Clinical study of partial cystectomy combined with chemotherapy for muscle-invasive bladder cancer

作　　者：王平[1] 沈思瑶[1] 薄隽杰[1] 张连华[1] 李铮[1] 刘东明[1] 黄翼然[1] 

机构地区：[1]上海交通大学医学院附属仁济医院泌尿外科,上海200001

出　　处：《中国癌症杂志》2012年第10期766-769,共4页China Oncology

摘　　要：背景与目的:肌层浸润性膀胱癌标准治疗为根治性膀胱切除术,对于部分不能耐受或不愿根治的患者可行保留膀胱治疗。本文拟探讨膀胱部分切除术联合化疗治疗肌层浸润性膀胱癌的疗效,分析相关影响因素及其应用价值。方法:收集2002年1月—2005年4月期间行膀胱部分切除术(partial cystectomy,PC)联合化疗(PC组)的52例肌层浸润性膀胱癌患者临床资料,对比同期47例根治性膀胱切除术(radical cystectomy,RC)的患者(RC组)总生存率(overall survival,OS)并进行统计分析。结果:PC组和RC组的OS差异无统计学意义(P>0.05),但T3期、肿瘤复发患者的OS PC组明显低于RC组(P<0.05)。结论:对于高选择性的患者,膀胱部分切除术联合化疗可作为治疗浸润性膀胱癌的有效方案。Background and purpose： For muscle-invasive bladder caner patients, the recommended treatment is radical cystectomy. While some patients are not suitable or unwilling to this treatment, bladder preserving treatment provides another choice. This research aimed to assess the curative effect, influencing factors of partial cystectomy plus chemotherapy for muscle-invasive bladder cancer. Methods： From Jan. 2002 to Apr. 2005, 52 patients with muscle-invasive bladder cancer underwent partial cystectomy plus chemotherapy （PC group）, contrast to 47 patients which underwent radical cystectomy （RC group）. The overall survival rates（OS） of the two groups were analyzed. Results： There is no significant difference of overall survival between the two groups （P=0.279）. For stage T3 and recurrent patients the PC group had significantly lower survival rates than RC group （P=0.048）. Conclusion： Partial cystectomy plus chemotherapy provides a choice for the treatment of muscle-invasive bladder cancer.

关 键 词：膀胱部分切除术 肌层浸润性膀胱癌 化疗 对比研究 

分 类 号：R737.14[医药卫生—肿瘤]