斑马鱼模型在中医药研究中的应用现状  

Use of zebrafish models for the research of traditional Chinese medicine

作　　者：王佑华[1,2] 黎晌[2] 杨彬睿[2] 张伦青[2] 周昕[1] 许贝文[2] 李铭源[2] 

机构地区：[1]上海中医药大学龙华医院高血压病研究室,上海200032 [2]中药质量研究国家重点实验室(澳门大学)澳门大学中华医药研究院

出　　处：《中西医结合学报》2012年第11期1189-1197,共9页Journal of Chinese Integrative Medicine

基　　金：国家科技部科技特派员专项(No.2009GJC00001);上海市自然科学基金资助项目(No.12ZR1432200);澳门科学技术发展基金资助项目(No.014/2011/A1)

摘　　要：中药及中药复方是一个复杂系统,中药药效物质是中医药发挥临床治疗作用的基础,中药药效筛选和评价方面的新技术新方法引进已成为学术界关注的问题。斑马鱼作为新型模式动物的优势正在逐渐被人们所认识,应用的领域也越来越宽广,其在中药药效筛选和评价中的应用日见广泛,并逐步扩展至毒性评价、药物代谢等多个方面。本文介绍了近年国内外斑马鱼模型在中医药研究中的应用概况,以期有利于中医药基础研究。Traditional Chinese medicine （TCM） exhibits a broad range of effects on biological activity that is probably due to interactions of complex chemical constituents with multiple targets in the body. Understanding the active chemical constituents in TCM is very important in providing rationales for the clinical usage of TCM. The zebrafish （Danio rerio） has recently become a popular model in the field of drug screening, specifically emerging as an important vertebrate model for in vivo high-content drug screening of multiple efficacy parameters and whole-organism toxicity. The authors also discussed the advantages of the zebrafish model for evaluating drug metabolism. Zebrafish usage in TCM screening should be a viable approach that helps identify active chemical markers, biological pathways and mechanistic actions of TCM.

关 键 词：斑马鱼 疾病模型 动物 中医药 综述 

分 类 号：R-332[医药卫生] R285