血清MMP-7和MMP-10的水平在卵巢癌诊断中的意义  

Significances of serum MMP-7 and MMP-10 levels for diagnosis of ovarian cancer

作　　者：王春红[1] 黄洪武 梁彬[3] 孙志刚[4] 

机构地区：[1]沈阳医学院教务处,辽宁沈阳110034 [2]江苏省昆山市公安局 [3]中国医科大学检验教研室 [4]中国医科大学病理教研室

出　　处：《中国妇幼保健》2012年第31期4964-4966,共3页Maternal and Child Health Care of China

基　　金：沈阳医学院2011年学院青年基金〔20112059〕

摘　　要：目的:探讨血清MMP-7和MMP-10的检测在卵巢癌诊断中的意义。方法:选取59例卵巢癌患者,52例卵巢良性肿瘤患者和40例健康体检妇女(正常对照组)为研究对象。采用ELISA方法测定血清中MMP-7和MMP-10的水平。结果:恶性组血清MMP-7和MMP-10的水平明显高于良性组和对照组(P<0.01)。良性组血清MMP-10水平高于对照组(P<0.01)。血清MMP-7和MMP-10的ROC曲线下面积分别为0.723和0.826。血清MMP-7和MMP-10的联合诊断灵敏度为95.2%,特异度为94.8%。结论:血清MMP-7和MMP-10的检测可以用于卵巢癌的诊断,两者联合诊断可大大提高卵巢癌的检出率。Objective： To explore the significance of joint detection of serum matrix metalloproteinase -7 （MMP -7 ） arid matrix metalloproteinase- 10 （MMP- 10） for diagnosis of ovarian cancer. Methods： A total of 59 patients with ovarian cancer, 52 patients with benign ovarian tumor, and 40 healthy women receiving physical examination （ control group） were recruited in this study. ELISA was used to detect the levels of MMP -7 and MMP - 10 in serum. Results： The serum levels of MMP -7 and MMP - 10 in ovarian cancer group were statistically significantly higher than those in benign ovarian tumor group and control group （ P 〈 O. 01 ） . The serum level of MMP - 10 in benign ovarian tumor group was statistically significantly higher than that in control group （P 〈 0. 01 ） . The areas under ROC curve of serum MMP - 7 and MMP - 10 were 0. 723 and 0. 826, respectively. The sensitivity and specificity of joint detection of serum MMP - 7 and MMP - 10 were 95.2% and 94.8%, respectively. Conclusion： Joint detection of serum MMP -7 and MMP - 10 can be used for diagnosis of ovarian cancer, which can significantly increase the detection rate of ovarian cancer.

关 键 词：卵巢癌 基质金属蛋白酶-7 基质金属蛋白酶-10 

分 类 号：R737.31[医药卫生—肿瘤]