电刺激丘脑腹外侧核对运动皮质2区放电的影响  

Effect of electrical ventrolateral thalamus nucleus stimulation on discharge from secondary motor cortex

作　　者：路致远[1] 丁方香[1] 王晓清[1] 计义正[1] 王敏[1] 

机构地区：[1]山东师范大学生命科学学院,济南250014

出　　处：《中华老年心脑血管病杂志》2012年第11期1206-1208,共3页Chinese Journal of Geriatric Heart,Brain and Vessel Diseases

基　　金：山东省科技发展计划项目(2010GGX10133);山东省自然科学基金(ZR2010CM055)

摘　　要：目的通过刺激帕金森病(PD)大鼠丘脑腹外侧核,观察运动皮质2区局部场电位的改变。方法选取成年雄性Wistar大鼠18只,随机分为对照组6只,实验组12只,实验组建立PD模型,采取信号后,实验组大鼠行电刺激,再采集信号,利用MATLAB软件进行频谱分析和功率谱密度分析。结果与对照组比较,实验组大鼠电刺激前8～12 Hz频段频率信号显著升高,26～40 Hz频段频率信号显著降低(P<0.05,P<0.01)。与电刺激前比较,实验组大鼠电刺激后8～12 Hz和13～25 Hz频段频率信号显著降低,26～40 Hz和41～100 Hz频段信号显著升高(P<0.05,P<0.01)。结论电刺激丘脑腹外侧核可以改善PD大鼠大脑运动皮质2区的异常放电。Objective To observe the local field potentials （LFP） in Secondary motor cortex by stimulating the ventrolateral thalamus nucleus in rats with PD. Methods Eighteen adult male Wistar rats were randomly divided into control group（n=6） and experiment group（n=12）. A rat PD model was established. LFP signals were colleced from the two groups and then from the ex- periment group after electrical stimulation. Their frequency sprectra and power density were ana- lyzed with the MATLAB software. Results The LFP signals at 8--12 Hz were much more while those at 26--40 Hz were much less in experiment group than in control group after electrical stimulation（P〈0.05,P〈0.01）.The LFP signals at 8--12 Hz and 13--25 Hz were much less while those at 26--40 Hz and 41--100 Hz were much more after electrical stimulation than before electrical stimulation（P〈0.05,P〈0.01）. Conclusion Electrical ventrolateral thalamus nucleus stimulation can improve the abnormal discharge from secondary motor cortex in PD rats. Key words： Parkinson disease; electric stimulation 〈 ventral thalamic nuclei ; local field potentials

关 键 词：帕金森病 电刺激 丘脑腹侧核 局部场电位 

分 类 号：R742.5[医药卫生—神经病学与精神病学]