CA153、CA125、CEA、AFP联合检测在乳腺癌诊断中的价值  

Study on Diagnostic Value of combined Detection of CA153, CA125, CEA and AFP in Breast Cancer

作　　者：卢晓峰[1] 张俊英[2] 孙淑明[1] 谢舜峰[1] 

机构地区：[1]汕头大学医学院第一附属医院甲状腺乳腺外科,广东汕头505041 [2]汕头大学医学院附属肿瘤医院信息科,广东汕头515041

出　　处：《中国医药指南》2012年第30期54-55,共2页Guide of China Medicine

摘　　要：目的探讨肿瘤标志物CA153、CA125、CEA、AFP在乳腺癌诊断的价值。方法对59例乳腺癌患者、81例乳腺良性疾病患者、60例健康女性进行血清CA153、CA125、CEA、AFP的检测,并进行对比分析。结果①乳腺癌组CA153、CA125、CEA水平分别高于乳腺良性疾病组和正常对照组;②乳腺癌组CA153、CA125、CEA、AFP的联合检测阳性率显著高于单项检测阳性率;③四项联检对乳腺癌诊断的特异性较单项略偏低,但准确性基本持平,敏感性明显提高。结论 CA153、CA125、CEA、AFP的联合检测可为临床诊断乳腺癌提供一定的帮助,但作用有限。Objective To Study the diagnosis value of tumor marker CA153,CA125,CEA and AFP in breast cancer.Methods The serum samples from 59 patients with breast cancer,81 patients with benign breast disorders and 60 healthy women were collected.The serum levels of CA153,CA125,CEA and AFP in these samples were tested and analyzed.Results ①The levels of CA153,CA125 and CEA in patients with breast cancer were higher than those in patients with benign breast disorders and normal controls.②The combined detection can increase positive rate significantly in the group of breast cancer.③ The combined detection can increase the diagnosis sensitivity in the group of breast cancer,but the specificity will be reduced and the veracity will be kept.Conclusion The combined detection of CA153,CA125,CEA and AFP is helpful to diagnose breast cancer,but the effect is limited.

关 键 词：CA153 CA125 CEA AFP 乳腺癌 肿瘤标志物 

分 类 号：R737.9[医药卫生—肿瘤]