口服普萘洛尔治疗婴幼儿血管瘤的临床效果观察  

Oral propranolol therapy in infants with hemangiomas clinical effect observation

作　　者：卫裴[1] 梁杰[1] 吴志贤[1] 徐孝兴[1] 史玉仓[1] 

机构地区：[1]广东医学院附属医院整形外科,广东湛江524001

出　　处：《中国美容医学》2012年第08X期36-37,共2页Chinese Journal of Aesthetic Medicine

基　　金：广东省湛江市科技攻关项目(编号:2008C02004)

摘　　要：目的:评价普萘洛尔治疗婴幼儿血管瘤的疗效。方法:按照严格的纳入、排除标准,成功筛选30例血管瘤患儿作为口服普萘洛尔的治疗对象,年龄为28天～10月,平均年龄4.8月。<3个月患儿,剂量1.5mg.kg-1.d-1;>3个月患儿,剂量2.5mg.kg-1.d-1,每天分2次服用。一般住院治疗5～7天,复查心电图、三大常规、肝肾功能、血糖、血脂及电解质等。如无异常予以出院带药。嘱患者出院后继续服药,用药前3个月,每2周复诊1次;3个月后每月复诊一次。结果:按四级评分法对药物疗效进行评估。治疗30例患儿,其中I级疗效有2例(差);Ⅱ级4例(中);Ⅲ级14例(好);Ⅳ级10例(优)。结论:口服普萘洛尔治疗婴幼儿血管瘤效果明显,副作用小,用药安全范围广,今后在临床上有望推广应用。Objective To investigate the efficacy of propranolol in the treatment of infantile hemangioma. Methods According to strict inclusion and exclusion criteria, we select 30 cases aged 28 days to 10 mouths with an average age of 4.8 months.They were divided to two.groups following the age： 〈3 mouths children with the dose of 1.5mg·kg^-1·d^-1;〉3 months children with the dose of 2.5mg·kg^-1·d^-1, all divided to 2 times. Generally hospitalized 5-7d,they were reviewed ECG, three conventional, liver and kidney function, blood glucose, lipids, elec- trolytes and so on. Results The therapeutic effects were evaluated using a 4-point scale system.All of the patients insisted on the treatment following prescription,among them,2 was scale I （poor）,4 was scale II （moderate）,14 was scale III （good）and 10 was scale IV （excellent）. Conclusion The effect of oral propranolol treatment in infantile hemangioma is reliable, with little side effects and a wide ranqe of druq safety.It will be popularized in future clinical application.

关 键 词：普萘洛尔 婴幼儿 血管瘤 

分 类 号：R739.5[医药卫生—肿瘤]