自然流产史染色体检查结果分析  

作　　者：甘志远[1] 胡少飞[1] 刘天圣[2] 

机构地区：[1]广西南宁市妇幼保健院遗传科,广西南宁530011 [2]广西壮族自治区妇幼保健院遗传中心

出　　处：《中国美容医学》2012年第08X期174-175,共2页Chinese Journal of Aesthetic Medicine

摘　　要：目的:探讨自然流产与染色体异常的关系,为临床诊断提供依据;方法:采集218对有自然流产史夫妻外周血,进行淋巴细胞培养,常规方法制片,G显带染色体核型分析;结果:检测出染色体异常核型17例,占受检夫妻的3.29%,其中平衡异位6例,倒位4例,染色体数目异常3例,罗伯逊异位2例,丢失2例;染色体多态变异46例,占受检夫妻的8.65%,主要表现为Y染色体、9号染色体、16号染色体多态变异;结论:染色体异常是导致自然流产的重要因素,应加强对有自然流产史夫妻的染色体检查,实现优生优育。objective To discussion the relationship between spontaneous abortion and chromosomal abnormalities, and provide bases for clinical diagnosis; Methods Collecting to 218 of natural history of abortion couples in peripheral blood lymphocytes, training, rou- tine rocedures, G banding karyotype analysis; Results Detection to 17 cases of abnormal karyotypes, accounted for 3.29% tested couples, which balanced ectopic 6 ,cases 4 inversion, chromosome abnormalities in 3 cases,2cases with ectopic Robertson, lost in 2cases;46 cases were chromosomal polymorphism variation, the couples accounted for 8.65%, mainly for the Y chromosome,9 chro- mosomal ,16 chromosomal polymorphism variation; Conclusion Chromosomal anomalies as a cause of spontaneous abortion are im- portant factors, should strengthen pair of natural abortion couples of chromosome examination, implementation of eugenics.

关 键 词：自然流产 染色体异常 核型分析 

分 类 号：R714.1[医药卫生—妇产科学]