初均速法预测补骨脂药材的有效期  

Stable life predection for Psoralea corylifolia by initial average rate stability test

作　　者：魏金凤[1] 薛志平[1] 刘杰 康文艺[1] 

机构地区：[1]河南大学中药研究所,河南开封475004 [2]河南省中医研究院,河南郑州450004

出　　处：《中国中药杂志》2012年第21期3176-3178,共3页China Journal of Chinese Materia Medica

基　　金：河南省科技厅重点项目(122102310272)

摘　　要：目的:用初均速温度加速实验法研究不同温度下药材补骨脂中有效成分补骨脂素和异补骨脂素总含量变化情况,预测补骨脂在室温(25℃)条件下的有效期,为评价其质量提供依据。方法:以lnV(V为反应初始速度)代替lnK(K为反应速率常数)对1/(T+273.15)作Arrhenius图的直线,以直线斜率求活化能Ea,直线外推得室温下贮存期。结果:补骨脂在室温条件下贮存期为0.53年。结论:高温不利于补骨脂的稳定,需置于避光阴凉处保存。Objective： To study the total content change of psoralea and isopsoralea in Psoralea corylifolia under different temperature, and predict its term of validity by initial average rate stability test in order to provide the basis for assessing its quality. Method： The reaction rate constant K was replaced by initial velocity V,,. According to Aixhenius rule, storage period was obtained at room temperature. Result： The stable life of P. corylifolia has been determined as 0. 53 years. Conclusion： The high temperature is not conducive to the stability of the P. corylifolia, which need to store in a dark and cool place.

关 键 词：初均速法 有效期 补骨脂 高效液相色谱法 

分 类 号：R284[医药卫生—中药学]