ER、PR、VEGF、CA15-3、CA125和CEA水平在乳腺癌预后判断中的临床意义  

Clinical significance of levels of ER,PR,VEGF,CA15-3,CA125 and CEA in the prognosis of patients with breast cancer

作　　者：许立生[1] 王水[2] 黄中晶[1] 赵志泓[1] 沈恩超[1] 钱超[1] 

机构地区：[1]江苏大学附属医院乳腺外科,江苏省镇江市212001 [2]南京医科大学第一附属医院,210029

出　　处：《实用医学杂志》2012年第21期3565-3567,共3页The Journal of Practical Medicine

摘　　要：目的:探讨乳腺癌预后判断中ER、PR的表达情况及VEGF、CA15-3、CA125和CEA水平的临床意义。方法:86例乳腺癌患者行手术治疗,术后标记ER与PR,统计表达情况和随访情况;同时检测VEGF、CA15-3、CA125和CEA水平,并与40例正常对照组指标比较,分析其与临床分期、复发转移情况及治疗效果的关系。结果:22例ER和PR均表达阴性。随访后,"双阴性"患者进展(PD)13例,稳定(SD)9例。乳腺癌组VEGF阳性率随临床分期(Ⅰ～Ⅳ)依次升高,淋巴结转移患者阳性率明显高于无转移者(P<0.05)。Ⅲ、Ⅳ期患者CA15-3、CA125和CEA水平显著高于Ⅰ、Ⅱ期和对照组,淋巴结转移患者明显高于无转移者(P<0.05)。复发者各项指标显著高于无复发者(P<0.05)。结论:联合检测ER、PR表达情况及VEGF、CA15-3、CA125和CEA水平有一定意义,可以指导乳腺癌诊疗工作。Objective To investigate the clinical significance of levels of ER, PR, VEGF, CA15-3, CA125 and CEA in the prognosis of patients with breast cancer. Methods Eighty-six cases of breast cancer were received surgical treatment, and levels of ER, PR, VEGF, CA15-3, CA125 and CEA were determined and compared with those in the control group （n = 40）. The relationship between the indexes and the clinical stages relapse, metastasis and treatment efficiency were analyzed. Results ER and PR expression in 22 cases were negative, and the following-up results showed that 13 cases were PD, 9 cases were SD. VEGF positive rate was higher with the rising of the clinical stage （ I - IV ） in the breast cancer groups. Positive rate of lymph node metastasis was significantly higher in the metastasis group. Levels of CA15-3, CA125 and CEA were significantly higher in breast cancer groups （III , IV ） than those in breast cancer groups （ I , lI ） and the control group. The indicators of recurrent were significantly higher in the cases with relapse than those without relapse. Conclusion Combination of ER, PR, VEGF, CA15-3, CA125 and CEA expression determination may have a definite clinical significance in the prognosis of patients with breast cancer.

关 键 词：乳腺肿瘤 ER PR 肿瘤标志物 预后 

分 类 号：R737.9[医药卫生—肿瘤]