肿瘤干细胞缺氧微环境的形成及其对肿瘤转移的促进作用  

Formation of hypoxic microenvironment of cancer stem cells and its role in tumor metastasis

作　　者：王洪海[1] 李连宏[2] 

机构地区：[1]大连医科大学教务处教务科,116044 [2]大连医科大学病理学与法医学教研室,116044

出　　处：《国际肿瘤学杂志》2012年第11期812-814,共3页Journal of International Oncology

摘　　要：肿瘤干细胞位于特定的微环境中，这些微环境在肿瘤细胞的增殖和转移中起到了重要的作用。缺氧是实体肿瘤组织微环境重要的特征之一，最近一系列研究结果表明缺氧微环境下可能是肿瘤干细胞促进肿瘤转移的重要环节，这一结果为理解肿瘤的发生机制和治疗肿瘤提供了新的线索。Cancer stem cells located in specific microenvironment, that play an important role in the proliferation ,and metastasis of tumor cells. Hypoxia is one of the important features of tumor tissue microenvironment. A series of studies results show that the hypoxic microenvironment of tumor stem cells could promote tumor metastasis, which provides new clues for understanding tumor pathogenesis and tumors treatment.

关 键 词：肿瘤干细胞 缺氧 缺氧诱导因子1 肿瘤转移 

分 类 号：R730.2[医药卫生—肿瘤]