热休克蛋白47在肺纤维化胶原加工中的作用  

Role of heat shock protein 47 in collagen processing of pulmonary fibrosis

作　　者：王凌伟[1] 陈春婵[1] 

机构地区：[1]深圳市人民医院、暨南大学第二临床医学院呼吸内科,518020

出　　处：《国际呼吸杂志》2012年第21期1671-1674,共4页International Journal of Respiration

基　　金：深圳市科技计划项目（200902023）

摘　　要：热休克蛋白47（HSP47）是胶原结合分子伴侣，参与前胶原的加工、折叠、合成及分泌，起着质量控制作用。肺纤维化存在胶原异常聚集及HSP47表达增多。在各种不同类型肺纤维化中，HSP47表达上调，与胶原表达正相关，但不同类型肺纤维化HSP47表达水平各异。现就HSP47在肺纤维化胶原表达加工的作用综述如下。Heat shock protein 47（HSP47） was a collagen-specific molecular chaperon. It was found to participate in pro-collagen processing, folding, synthesis and secretion, functioned as “quality control”. HSP47 was upregulated and had positive relation with collagen expression which was abnormally aggregated in pulmonary fibrosis. Increased expression of HSP47 was found in various pulmonary fibrotic diseases with different level. Here we reviewed the articles about the function of HSP47 in collagen processing of pulmonary fibrosis.

关 键 词：肺纤维化 热休克蛋白47 胶原 

分 类 号：R363[医药卫生—病理学]