局限期小细胞肺癌术前化疗周期对术后临床疗效的影响  

Effect of preoperative neo-adjuvant chemotherapy cycles on postoperative clinical effect in the treatment of limited staged small cell lung cancer

作　　者：陈强[1] 王化勇[1] 胡正群[1] 陈伟钢[1] 

机构地区：[1]江苏省徐州市中心医院胸外科,徐州221009

出　　处：《临床医学》2012年第10期1-2,共2页Clinical Medicine

摘　　要：目的探讨手术结合新辅助化疗治疗局限期小细胞肺癌术前化疗周期对术后临床疗效的影响。方法回顾性分析150例局限期小细胞肺癌(Ⅰ～Ⅱ期)手术患者的临床资料,术前予不同的化疗周期(1个周期、2个周期及3个周期以上),术后化疗6个周期。比较术前不同周期化疗患者5年生存率及术前不同周期化疗对化疗的毒性反应及对术后并发症的影响。结果根治性手术术前化疗2个周期组5年存活率明显较术前化疗1个周期组、3个周期以上组高(P<0.05);术前化疗2个周期组骨髓抑制、肝肾功能异常及术后并发症发生率与术前化疗1个周期组比较差异无统计学意义(P>0.05),但较术前化疗3个周期以上组明显降低(P<0.05)。结论根治性手术结合术前化疗2个周期治疗局限期小细胞肺癌可获得满意的临床效果,且不增加手术危险性。Objective To investigate the effect of preoperative chemotherapy cycle on postoperative clinical effect for patients with limited stage small cell lung cancer treated by surgery combined with neo-adjuvant chemotherapy. Methods The clinical data of 150 patients with limited stage small cell lung cancer were retrospectively analyzed, different chemotherapy cycles（ 1 cy- cle, 2 cycles and above 3 cycles） were given preoperatively, 6 cycles of chemotherapy were give postoperatinely. The clinical outcomes and chemotherapy toxic reaction of different preoperative chemotherapy cycle on limited stage small cell lung cancer pa- tients were compared. Results The 5 years survival rate in patients with 2 cycles of preoperative chemotherapy was higher than patients with preoperative chemotherapy of 1 cycle and above 3 cycles （ P 〈 0. 05 ）. There was no significant difference in the chemotherapy toxic reaction and postoperative complications between patients with preoperative chemotherapy of 2 cycles and 1 cycle, but decreased more obviously than those of patients with above 3 cycles of preoperative chemotherapy （ P 〈 0. 05 ）. Conclusion Radical surgery combined with pre-operative chemotherapy of two cycles can obtain satisfactory clinical effect for cimited small cell lung cancer, and doesn＇t increase the side effects.

关 键 词：小细胞肺癌 外科手术 新辅助化疗 

分 类 号：R734.2[医药卫生—肿瘤]