17aα-D-高炔雌二醇-3-乙酯联合化疗抗肿瘤作用研究  

The antitumor effect of 17aα-D-homoethynylestradiol-3-acetate combined with chemotherapy

作　　者：吴红英[1] 王月英[1] 张恒[1] 李德冠[1] 王小春[1] 李进[1] 杜利清[1] 王彦[1] 褚丽萍[1] 孟爱民[1] 

机构地区：[1]北京协和医学院中国医学科学院放射医学研究所天津市分子核医学重点实验室,天津300192

出　　处：《陕西医学杂志》2012年第11期1443-1444,1466,共3页Shaanxi Medical Journal

基　　金：国家973重大专项(2011CB964800-G);国家自然科学基金项目(81072237;81102873;81129020);教育部高等学校博士学科点专项基金项目(20111106110038);天津市自然科学基金项目(12JCQNJC09100;11JCZDJC19100)

摘　　要：目的:观察17aα-D-高炔雌二醇-3-乙酯及其联合化疗对EC901食管癌的抑制作用。方法:将接种EC901瘤细胞的裸鼠分为对照组、17aα-D-高炔雌二醇-3-乙酯组、5-氟尿嘧啶(5-Fu)组、17aα-D-高炔雌二醇-3-乙酯联合5-Fu组,连续给药9d,分别检测肿瘤抑制率、外周血常规、骨髓有核细胞计数、肿瘤病理等指标。结果:17aα-D-高炔雌二醇-3-乙酯治疗组瘤重明显小于对照组,联合5-Fu组肿瘤生长分别低于5-Fu组和照射组。结论:17aα-D-高炔雌二醇-3-乙酯联合5-Fu对EC901食管癌的抑制具有增效作用。Objective：To observe the inhibition effects of 17aα-D-homo-ethynylestradiol-3-acetate and combination with chemotherapy on esophageal carcinoma EC901.Methods：Inoculate the nude mice with esophageal cancer cells EC901 and then divided them into four treatment groups：17aα-D-homo-ethynylestradiol-3-acetate,5-Fu,17aα-D-homo-ethynylestradiol-3-acetate combined with 5-Fu and control group.Each group were continuous deliveried drugs for 9 days.After days,the inhibition rate of tumor,blood count,nucleated cell in bone marrow were examined.Results：Tumors of 17aα-D-homo-ethynylestradiol-3-acetate group were apparently lighter than control group.Compared with 17aα-D-homo-ethynylestradiol-3-acetate group and 5-Fu group,the growth of tumors in 17aα-D-homo-ethynylestradiol-3-acetate combined with 5-Fu group was slower.Conclusion：17aα-D-homo-ethynylestradiol-3-acetate combined with 5-Fu can increase the inhibition effects to EC901esophageal cancer.

关 键 词：食管肿瘤 放射疗法 @17aα-D-高炔雌二醇-3-乙酯 @肿瘤抑制 氟尿嘧啶 治疗应用 小鼠 

分 类 号：R733[医药卫生—肿瘤]