腹膜透析并发感染性腹膜炎患者血清降钙素原检测的临床意义  

Clinical significance of serum procalcitonin in patients with peritoneal dialysis complicated with infectious peritonitis

作　　者：菅宏蕴[1] 崔惠敏[1] 何映琴[1] 林建[1] 刘远浩[1] 

机构地区：[1]中山大学附属中山医院肾内科,广东中山528403

出　　处：《临床医学》2012年第8期17-18,共2页Clinical Medicine

摘　　要：目的探讨血清降钙素原(PCT)对腹膜透析相关性腹膜炎患者的诊断、疗效观察中的应用价值。方法检测30例腹膜透析相关性腹膜炎患者和30例腹膜透析无相关性腹膜炎患者为对照组,检测血清PCT、C-反应蛋白(CRP)、白细胞(WBC)的浓度,并动态观察以上各指标在腹膜透析相关性腹膜炎患者治疗前后的变化。结果 PCT与CRP治疗前后比较差异有统计学意义(P<0.05);WBC治疗前后变化不明显(P>0.05)。结论 CRP、PCT是诊断腹膜透析相关性腹膜炎的较好指标;CRP与PCT在腹膜透析相关性腹膜炎患者经有效抗感染治疗后均可发生显著变化,联合检测CRP和PCT对腹膜透析相关性腹膜炎的疗效观察具有重要的临床意义。Objective To investigate the application value of serum procaleitonin（PCT） on diagnosis and efficacy observation of continuous ambulatory peritoneal dialysis patients with peritoneal dialysis-related peritonitis. Methods Thirty cases of contin- uous ambulatory peritoneal dialysis patients with peritoneal dialysis-related peritonitis and 30 cases of no PD-related peritonitis continuous ambulatory peritoneal dialysis were tested by PCT, C-reactive protein （ CRP）, white blood cell （WBC）in 24 hours. The changes of above indexes were observed dynamically before and after the treatment of PD-related peritonitis. Results There were significant differences in PCT and CRP before after treatment （ P 〈 0.05 ） ; But there was no significant difference in WBC （ P 〉 0.05 ）. Conclusion （1）PCT and CRP are helpful for diagnosing PD-related peritonitis ; （2）The combined detection of CRP and PCT on the efficacy of PD - related peritonitis has important clinical significance.

关 键 词：降钙素原 C-反应蛋白 腹膜透析相关性腹膜炎 诊断 疗效监测 

分 类 号：R575.2[医药卫生—消化系统]