前列腺癌骨转移内分泌治疗合并贫血的临床观察  

Clinical observation of anemia in patients with prostatic carcinoma osseous metastasis accepted hormonal therapy

作　　者：薛鹏[1] 王祥波[1] 涂传全[1] 张志刚[1] 赵海岩[1] 杨光天[1] 杨文发[1] 

机构地区：[1]连云港市第一人民医院泌尿外科,江苏连云港222000

出　　处：《临床泌尿外科杂志》2012年第11期851-852,共2页Journal of Clinical Urology

摘　　要：目的:观察前列腺癌骨转移及接受内分泌治疗对患者造血功能的影响。方法:对38例前列腺癌骨转移患者采用内分泌治疗(联合雄激素阻断,睾丸切除+氟他胺,250mg/次,3次/d)。分别于治疗前及治疗后1、3、6个月检查血红蛋白(Hb)及红细胞压积(Ht),5例患者行骨髓穿刺细胞学检查。结果:前列腺癌骨转移合并贫血患者27例(71%),血小板减少7例,5例骨穿患者除1例骨髓"干抽"外,余4例骨髓涂片可见肿瘤细胞分布。治疗前及治疗后1、3、6个月Hb分别为(104±16)、(89±14)、(84±15)、(81±14)g/L;Ht分别为(0.321±0.035)、(0.292±0.036),(0.284±0.038),(0.281±0.036)。治疗前后相比均差异有统计学意义(P<0.05)。结论:前列腺癌骨转移严重影响患者造血功能,内分泌治疗可导致或加重患者贫血。Objective：To investigate the influence of prostatic carcinoma osseous metastasis and hormonal ther- apy on the haematogenesis function. Method： Thirty-eight patients with prostatic carcinoma osseous metastasis were treated by combined androgen block（orchiectomy and flutamide 250mg,tid）. Complete blood counts were de- tected before initiation and after 1 .3 and 6 months of therapy, and 5 cases accepted bone marrow aspiration cyto- logical examination. Result： There were 71% （27/38） patients with anemia, 7cases with thrombocytopenia, and tumor cells were found in the film preparation of 4 cases in the 5 patients accepted bone marrow aspiration cytolog- ical examination. Marrow ＂dry-draw＂ （marrow couldnt be got when bone marrow aspiration being done）took place in 1 case. Hb level decreased from a mean baseline of （104±16） g/L to（89±14） g/L, （84±15） g/L, （81±14） g/ L after 1. 3 and 6 months of therapy. Ht decreased from a mean baseline of （0. 321±0. 035） to （0. 292±0. 036）, （0. 284±0. 038）, （0. 281±0. 036）. The differences between before and after treatment were significant（P〈0.05）. Conclusion：There is great influence of prostatic carcinoma osseous metastasis on the haematogenesis function, and hormonal therapy can also cause anemia or even deteriorate it.

关 键 词：前列腺癌 骨转移 内分泌治疗 贫血 

分 类 号：R737.25[医药卫生—肿瘤]