2001-2010年温州地区川崎病住院患儿流行病学调查  

Epidemiologic study of children admitted to hospital with Kawasaki disease in Wenzhou from 2001 to2010

作　　者：张营营[1] 张园海[2] 周爱华[1] 王丹[1] 岳亚延[1] 潘璐璐[1] 吴蓉洲[2] 陈其[2] 项如莲[2] 褚茂平[1] 

机构地区：[1]温州医学院附属第一医院心脏中心儿科,温州325000 [2]温州医学院附属儿童医院心血管科,温州325000

出　　处：《中华风湿病学杂志》2012年第11期763-766,共4页Chinese Journal of Rheumatology

基　　金：浙江省自然科学基金（2011C37089）

摘　　要：目的了解温州地区川崎病住院患儿的发病情况及流行病学特征，为早期诊断和及时治疗川崎病，降低冠状动脉损害（CAL）的发病率提供科学依据。方法采用北京儿童医院杜忠东教授提供的川崎病流行病学调查表，对2001年1月1日至2010年12月31日温州地区经住院治疗的全部川崎病患儿进行回顾性调查研究。结果2001-2010年符合川崎病诊断标准的病例数为827例，其中完全川崎病占74．12％，不完全川崎病占25．88％。男女性别比为2．28：1；发病年龄为37d至13岁，高峰年龄为1岁；全年均可发病，但以4-6月为发病高峰。急性期发生心血管损害者占34．6％，以冠状动脉扩张最为常见，发生冠状动脉瘤者16例（1．9％）。丙种球蛋白耐药者53例，占6．41％。再发者12例，复发比例为1．5％。治疗后发生粒细胞减少或缺乏者114例（13．8％），患儿急性期无死亡。结论温州地区川崎病患儿发病例数有逐年增多趋势，急性期心血管损害发生情况与广东、北京调查结果相似，高于日本调查结果。Objective To evalute the incidence and epidemiologic characteristics of Kawasaki disease （KD） in Wenzhou, China. Methods We used a questionnaire survey and reviewed the medical records and reports of all patients with KD diagnosed during the 10 year periods from January, 2001 to December, 2010. Results We studied 827 inpatients diagnosed with KD during the 10-years period from 2001 to 2010. There were 613 cases （74.12%） with complete KD. The ratio of male to female ratio was 2.28：l.Age at onset ranged from 37 days to 13 years old, and the peak age group was 1 year old. The disease occurred in all of the seasons, but the peak was from April to June. The incidence of cardiovascular damage in acute KD was 34.6%, and the most common sequela was coronary artery dilatation. There werel6 patients with coronary aneurysm. Fifty-three patients did not respond to immunoglobulin （6.4%）, and 12 patients （ 1.5% ） developed recurrent KD. After treatment, 114 cases （13.8%） developed neutropenia. There were no deaths during hospitalization. Conclusion Patients with KD has become more and more in Wenzhou. Cardiovascular damages were similar to those in Beijing and Guangzhou, but higher than that reported in Japan.

关 键 词：黏膜皮肤淋巴结综合征 流行病学 儿童 

分 类 号：R725.4[医药卫生—儿科]