自体骨髓间充质干细胞移植治疗脑出血的疗效观察  

Effect of autologous bone marrow mesenchymal stem cells transplantation for cerebral hemorrhage

作　　者：李计成[1] 李晓明[1] 戴如飞[1] 蔡军[1] 

机构地区：[1]徐州医学院第二附属医院神经外科,徐州221006

出　　处：《中国实用神经疾病杂志》2012年第20期8-10,共3页Chinese Journal of Practical Nervous Diseases

摘　　要：目的探讨自体骨髓间充质干细胞治疗脑出血近期有效性和安全性。方法 2009-01—2012-01我院神经外科收治的脑出血患者45例。移植组20例通过蛛网膜下腔注射方式行自体骨髓间充质干细胞移植,选择同期入院但未行干细胞移植的25例作为对照组。分别于移植前和移植后6个月进行神经功能缺损程度评定(NIHSS评分)和日常生活活动能力评定(Barthel指数)。同期随访血常规、生化全项、肿瘤标记物以观察其安全性。结果移植前2组NIHSS评分及Barthel指数基本相似。与对照组比较,移植后6个月治疗组NIHSS评分显著降低(P<0.05),Barthel指数显著升高(P<0.05)。与移植前比较,治疗组在移植后6个月NIHSS评分显著降低(P<0.05),BaRhel指数显著升高(P<0.05)。2例患者在移植后出现一过性发热,予对症处理后症状缓解。随访各项血液检查结果无明显异常。结论采用自体骨髓间充质干细胞治疗脑出血临床疗效安全有效,近期临床疗效明显,远期治疗效果有待观察。Objective To observe a short-term effect and safety of autologous bone marrow mesenchymal stem cell trans- plantation in treatment of cerebral hemorrhage. Methods A total of 45 patients with cerebral hemorrhage were collected from January 2009 to January 2012 in the neurosurgery department of our hospital. The transplantation group （n= 20） was treated with autologous bone marrow mesenchymal stem cell transplantation by subarachnoid space injection. The control group （n= 25） was not treated with stem cell transplantation. Neurologic impairment（NIHSS）and activities of daily living （Barthel index） were performed before and 6 months after transplantation, meanwhile, the blood routine,biochemical items and tumor marker were evaluated to detect the security of stem cell transplantation. Results The NIHSS score and Barthel index in the transplan- tation group before transplantation were similar to those in the control group. Compared with control group, NIHSS score was significantly decreased in the treatment group（P〈0.05）, and Barthel index was significantly increased 6 months after trans- plantation（P〈0. 05）. Compared with before transplantation in the transplantation group, we received the same results 6 months after transplantation. Two patients had febrile, which recovered after treatment. There was no significant difference of blood examination results in the followed-up. Conclusion The autologous bone marrow mesenehymal stem cell transplantation in treatment of cerebral hemorrhage is safe and effective in a short-term period;however, the long-term effect still needs to be further studied.

关 键 词：脑出血 间充质干细胞 移植 

分 类 号：R743.34[医药卫生—神经病学与精神病学]