含1,3,4-噁二唑和哌嗪的酰胺类化合物的合成及表征  

Synthesis and characterization of amide deritives containing 1,3,4-oxadiazole and piperazine

作　　者：朱文娟[1] 于知冉[1] 王海卫[1] 马姣丽[1] 吕志丹[1] 廖新成[1] 

机构地区：[1]郑州大学化学系,河南郑州450052

出　　处：《化学试剂》2012年第11期975-981,1032,共8页Chemical Reagents

基　　金：国家自然科学基金资助项目(21171149)

摘　　要：以无水哌嗪、水合肼和芳甲酸为初始原料,经过酯化、肼解、环化、亲核取代、缩合等一系列反应,得到了哌嗪的1,4-位分别被芳酰基和1,3,4-噁二唑类化合物取代的20个未见报道的新化合物,并且所有目标化合物均经1HNMR、13CNMR、IR、MS、HRMS确认结构。Twenty target molecules with aroyl and 1,3,4-ox- adiazole substitutes in 1,4-position of piperazine rings were synthesized by esterification, hydrazinolysis, cyclization, nu- cleophilic substitution and condensation reaction with the raw material of anhydrous piperazine, hydrazine hydrate and aro- matic acids. All these compounds have not been reported in literature,and the structures of twenty compounds were con- firmed by IHNMR,13CNMR,IR,MS and HRMS.

关 键 词：哌嗪 1 3 4-噁二唑 芳酰基 酰胺 

分 类 号：O626[理学—有机化学]